Mycofin Rp 250 mg tablets and Mycofin 10 mg/g cream – terbinafine for fungal skin and nail infections

Mycofin is an antifungal medicine containing terbinafine. This page covers two pharmaceutical forms:

• Mycofin Rp 250 mg tablets – prescription systemic treatment for selected fungal infections of the skin and nails;
• Mycofin 10 mg/g cream – non-prescription local treatment for interdigital athlete’s foot and fungal infection of the groin.

The tablets and cream are not interchangeable. The appropriate form depends on the site, severity and extent of infection, appearance of the lesions, other medical conditions and concurrent treatment.

Mycofin – differences between the tablets and cream

Mycofin Rp tablets – approved uses

The tablets are used in adults for fungal infections caused by susceptible dermatophytes:

• tinea pedis when oral treatment is appropriate because of the location, severity or extent;
• tinea corporis;
• tinea cruris;
• onychomycosis of the fingernails or toenails.

Visible improvement of an infected nail may continue long after the tablets have been completed because a new healthy nail must grow and replace the damaged part.

Dosage and treatment duration

The usual adult dose is 250 mg once daily.

• Tinea pedis: usually 2–6 weeks.
• Tinea corporis: approximately 4 weeks.
• Tinea cruris: usually 2–4 weeks.
• Onychomycosis: commonly 6 weeks to 3 months; some infections of the great toenail may require 6 months or longer.

Swallow the tablet with water, preferably at approximately the same time every day. It may be taken with or without food.

The tablet can be divided into equal doses, but the prescribed dose must not be changed independently.

Liver-function monitoring

Stop taking the tablets and contact the doctor promptly if persistent nausea, loss of appetite, unusual tiredness, right upper abdominal pain, unexplained itching, yellow skin or eyes, dark urine or pale stools occur.

Contraindications and precautions

• allergy to terbinafine or another ingredient;
• chronic or active liver disease;
• significant kidney impairment without specialist assessment;
• use in children is not recommended because data are limited;
• breastfeeding.

Particular caution is required in patients with psoriasis, systemic lupus erythematosus or previous liver or kidney problems.

Important interactions

Tell the doctor about rifampicin, cimetidine, fluconazole, ketoconazole, amiodarone, selected antidepressants, beta-blockers, MAO-B inhibitors, dextromethorphan, ciclosporin, warfarin and other medicines requiring close monitoring.

Irregular menstrual cycles or breakthrough bleeding have occasionally been reported in patients using oral contraceptives.

Pregnancy, breastfeeding and driving – tablets

Oral terbinafine should be used during pregnancy only when treatment is clearly required and the expected benefit justifies the possible risk.

Terbinafine passes into breast milk, so the tablets must not be used while breastfeeding.

Patients who experience dizziness should not drive or operate machinery.

Possible tablet side effects

Possible effects include reduced appetite, indigestion, nausea, abdominal discomfort, diarrhoea, rash, hives, muscle or joint pain and headache.

Taste disturbance or loss, reduced body weight, dizziness, numbness, tiredness, hair loss, altered smell, tinnitus, visual disturbance and worsening psoriasis have also been reported.

Mycofin 10 mg/g cream

The cream is intended for adults and adolescents over 16 years for:

• interdigital athlete’s foot;
• tinea cruris affecting the groin and inner thighs.

It is not intended for fungal infection inside the nail plate and must not be applied to the face.

How to apply the cream

Apply once daily for seven days.

1. Wash the affected area and dry it completely.
2. Apply a thin layer to the affected skin and the immediate surrounding area.
3. Rub in gently.
4. Areas between the toes or in the groin fold may be covered with clean gauze, particularly at night.
5. Wash the hands after application.

If there is no improvement two weeks after starting treatment, or the condition becomes worse, consult a doctor or pharmacist.

Cream precautions and side effects

• for external use only;
• avoid the face and eyes;
• rinse the eyes thoroughly with water after accidental contact;
• use below 16 years is not recommended;
• do not use during breastfeeding;
• do not use in case of allergy to terbinafine or another ingredient.

Peeling, itching, redness, burning, dry skin, crusting, irritation, pain, pigment changes, contact dermatitis or eczema may occur.

Composition, packs and manufacturer

• Tablets: 250 mg terbinafine per tablet; one blister containing 14 white scored tablets.
• Cream: 10 mg terbinafine hydrochloride per gram; aluminium tube containing 15 g.
• Tablet ATC code: D01BA02.
• Cream ATC code: D01AE15.
• Authorisation holder: Representative Office of Nobel Ilac Sanayii ve Ticaret AS, Belgrade.
• Manufacturer: Nobel Ilac Sanayii ve Ticaret A.S., Duzce, Türkiye.

Storage

Tablets: store below 25°C in the original packaging.

Cream: keep in the original packaging to protect it from light. After first opening, use within six months when stored below 25°C.

Related care and education

Explore: Foot care and insoles.

Read: What is the fastest way to treat nail fungus?

For practical prevention advice: How to remove fungi from shoes and disinfect them.

Sources: official Serbian patient leaflets, Summaries of Product Characteristics and packaging texts approved by ALIMS.
Mycofin Rp tablets leaflet | Mycofin cream leaflet
Information checked: 3 August 2026.