Tritace 2.5 mg, 5 mg and 10 mg tablets (ramipril) – for high blood pressure and heart and kidney protection

Tritace is a medicine containing the active substance ramipril, which belongs to the group of ACE inhibitors (angiotensin-converting enzyme inhibitors). It is available as 2.5 mg, 5 mg and 10 mg tablets.

Ramipril reduces the production of substances in the body that can raise blood pressure, relaxes and widens blood vessels and makes it easier for the heart to pump blood around the body. This is why Tritace is used for high blood pressure and also to protect the heart, blood vessels and kidneys.

What is Tritace (ramipril) used for and how should it be taken correctly?

Basic information about the medicine

What is Tritace used for?

• treatment of high blood pressure (hypertension);
• reducing the risk of heart attack or stroke (cardiovascular prevention in people with established heart and vascular disease or with diabetes and at least one other risk factor);
• reducing the risk or delaying the worsening of kidney disease (whether or not you have diabetes);
• treatment of heart failure, when the heart cannot pump enough blood;
• treatment after a heart attack (myocardial infarction) complicated by heart failure.

How is it used and dosed?

Tritace is taken by mouth at the same time every day, with or without food. Swallow the tablet whole with enough liquid – do not crush or chew it. The doses in the leaflet are a guide; the doctor adjusts them until the condition is under control.

If you already take diuretics (water tablets), the doctor may reduce their dose or stop them before starting treatment. A 1.25 mg dose is obtained with half of a 2.5 mg tablet.

Special patient groups

• Children and adolescents under 18: not recommended because there are no data on safety and efficacy.
• Elderly: the doctor starts with a lower dose and increases it gradually; in very old and frail patients a starting dose of 1.25 mg may be considered.
• Kidney impairment: the dose is adjusted to creatinine clearance – with clearance of 30–60 mL/min the maximum daily dose is 5 mg, and with 10–30 mL/min the starting dose is 1.25 mg and the maximum 5 mg daily (SmPC). On haemodialysis the medicine is taken a few hours after dialysis.
• Liver impairment: treatment is started under close medical supervision and the maximum daily dose is 2.5 mg (SmPC).

Contraindications – when the medicine must not be used

• allergy to ramipril, other ACE inhibitors or any of the excipients;
• a past serious allergic reaction called angioedema (swelling of the face, lips, tongue or throat, difficulty breathing and swallowing);
• current or recent treatment with sacubitril/valsartan (a medicine for chronic heart failure);
• dialysis or another type of blood filtration for which the medicine may not be suitable;
• narrowing of the kidney arteries (renal artery stenosis) with reduced blood flow to the kidneys;
• the second and third trimester of pregnancy;
• abnormally low blood pressure;
• diabetes or impaired kidney function together with a blood pressure medicine containing aliskiren.

Precautions and warnings

Talk to your doctor before starting treatment:

• if you have heart, liver or kidney problems;
• if you have lost a lot of salt or fluid (vomiting, diarrhoea, heavy sweating, low-salt diet, long-term diuretics, dialysis);
• if you are going to have desensitisation treatment for bee or wasp stings;
• before anaesthesia, surgery or dental treatment – you may need to stop the medicine one day before, as agreed with your doctor;
• if you have high potassium in your blood, or conditions or medicines that lower blood sodium;
• if you take mTOR inhibitors (temsirolimus, everolimus, sirolimus), vildagliptin or racecadotril – increased risk of angioedema;
• if you have collagen vascular disease (e.g. scleroderma, systemic lupus erythematosus);
• if you take sartans (e.g. valsartan, telmisartan, irbesartan) or aliskiren.

During treatment the doctor may regularly check your kidney function, blood pressure and blood electrolytes (e.g. potassium).

Interactions with other medicines, food and drink

Medicines that may reduce the effect of Tritace: NSAIDs (ibuprofen, indometacin, acetylsalicylic acid) and medicines such as ephedrine, noradrenaline or adrenaline.

Medicines that may increase the risk of side effects with Tritace:

• sacubitril/valsartan, NSAIDs, chemotherapy;
• ciclosporin, everolimus, sirolimus, temsirolimus;
• diuretics (e.g. furosemide);
• medicines that raise potassium: spironolactone, triamterene, amiloride, potassium salts, trimethoprim (also combined with sulfamethoxazole), heparin;
• corticosteroids (e.g. prednisolone), allopurinol, procainamide, vildagliptin, racecadotril;
• sartans and aliskiren (the doctor may need to change the dose).

Tritace may increase the effect of diabetes medicines (tablets and insulin – blood sugar should be checked more often) and raise blood levels of lithium.

Alcohol with Tritace may cause dizziness and light-headedness and lower blood pressure further – ask your doctor. The medicine can be taken with or without food.

Pregnancy and breastfeeding

Tritace should not be taken during the first 12 weeks of pregnancy and must not be used after week 13, as it may seriously harm the unborn baby. If you become pregnant during treatment, tell your doctor straight away; if you are planning a pregnancy, you should switch to another treatment in advance.

Tritace must not be taken while breastfeeding.

Driving and using machines

Dizziness may occur during treatment, more often at the start or when the dose is increased. If this happens, do not drive or use tools or machines.

Possible side effects

• Common: headache, tiredness, dizziness (especially at the start or after a dose increase), fainting, low blood pressure on standing up quickly, dry tickly cough, sinusitis, bronchitis, shortness of breath, stomach pain, diarrhoea, indigestion, nausea, vomiting, rash, chest pain, muscle cramps or pain, high blood potassium.
• Uncommon: vertigo, itching and tingling of the skin, loss of or change in taste, sleep problems, low mood, nervousness, blocked nose, worsening of asthma, intestinal angioedema (abdominal pain, vomiting, diarrhoea), heartburn, constipation, dry mouth, increased urination and sweating, reduced appetite, fast or irregular heartbeat, swelling of arms and legs, flushing, blurred vision, joint pain, fever, sexual problems, changes in blood tests.
• Rare: confusion, red swollen tongue, severe flaking of the skin, nail problems, bruising, cold extremities, red swollen eyes, ringing in the ears, weakness, reduced blood cell counts.
• Very rare: increased sensitivity to sunlight.
• Other reported: low blood sodium, Raynaud's phenomenon, breast enlargement in men, hair loss, disturbed sense of smell.

Overdose, missed dose and stopping treatment

• Overdose: contact a doctor or the nearest hospital straight away; do not drive yourself – ask someone to take you or call an ambulance, and take the pack with you.
• Missed dose: take the next dose at the usual time; never take a double dose.
• Stopping treatment: keep taking the medicine until your doctor tells you otherwise – long-term treatment protects the heart, blood vessels and kidneys.

Related information

For home blood pressure monitoring during treatment, see also the category Blood pressure devices – products in this category do not replace the medicine prescribed for you.

Composition, pack and manufacturer

• active substance: ramipril 2.5 mg, 5 mg or 10 mg per tablet;
• excipients: hypromellose; maize starch, pregelatinised; microcrystalline cellulose; sodium stearyl fumarate; the 2.5 mg tablets also contain yellow iron oxide (E172) and the 5 mg tablets red iron oxide (E172);
• appearance: oblong scored tablets – 2.5 mg yellowish to yellow, 5 mg light red, 10 mg white to almost white;
• pack: carton with 2 blisters of 14 tablets (28 tablets) for each strength;
• the medicine is essentially sodium-free (less than 1 mmol sodium per tablet);
• marketing authorisation holder: Amicus SRB d.o.o., Belgrade; manufacturer: Sanofi S.r.l., Scoppito (AQ), Italy;
• authorisations: 515-01-00446-23-001 (2.5 mg), 515-01-00447-23-001 (5 mg) and 515-01-00448-23-001 (10 mg) of 16.11.2023.

Storage

• Keep out of the sight and reach of children.
• This medicine does not require any special storage conditions.
• Do not use after the expiry date.

Frequently asked questions

Why can Tritace make me cough?

A dry, tickly cough is a common side effect of ramipril and other ACE inhibitors. If the cough persists or bothers you, see your doctor, who will assess further treatment – do not stop the medicine yourself.

Can I take Tritace with ibuprofen?

NSAID painkillers such as ibuprofen, indometacin and acetylsalicylic acid may reduce the effect of Tritace and increase the risk of side effects. Ask your doctor or pharmacist before taking a painkiller.

Should Tritace be taken before or after meals?

Tritace can be taken with or without food, at the same time every day. Swallow the tablet whole with enough liquid, without crushing or chewing.

What if I become pregnant while taking Tritace?

Tell your doctor straight away. The medicine is not recommended in the first 12 weeks of pregnancy and must not be used after week 13, as it may seriously harm the baby; your doctor will switch you to a suitable treatment.

Sources

• ALIMS – Patient information leaflet Tritace 2.5 mg (PIL)
• ALIMS – Summary of product characteristics Tritace 2.5 mg (SmPC)
• ALIMS – Patient information leaflet Tritace 5 mg (PIL)
• ALIMS – Summary of product characteristics Tritace 5 mg (SmPC)
• ALIMS – Patient information leaflet Tritace 10 mg (PIL)
• ALIMS – Summary of product characteristics Tritace 10 mg (SmPC)

Sources checked on: 25 October 2026.