Clindamycin-MIP 300 mg and 600 mg film-coated tablets – clindamycin, an antibiotic for bacterial infections

Clindamycin-MIP contains clindamycin (as clindamycin hydrochloride), an antibiotic used to treat acute and chronic bacterial infections caused by bacteria sensitive to clindamycin.

In Serbia it is registered as 300 mg and 600 mg film-coated tablets (marketing authorisation holder MIP Pharma d.o.o. Beograd, manufacturer MIP Pharma GmbH, Germany) and is available on prescription only. In severe infections treatment is usually started with clindamycin given into a vein.

What is Clindamycin-MIP used for and how should it be taken correctly?

Key facts about the medicine

What is Clindamycin-MIP used for?

According to the leaflet, Clindamycin-MIP 300 mg and 600 mg film-coated tablets are used to treat acute and chronic bacterial infections caused by bacteria sensitive to clindamycin, such as:

• bone and joint infections;
• ear, nose and throat infections;
• dental and jaw infections;
• lower respiratory tract infections;
• pelvic and abdominal infections;
• infections of the female genital organs;
• skin and soft tissue infections;
• scarlet fever.

The medicine is not effective for treating meningitis, as concentrations in the cerebrospinal fluid are insufficient.

How is it taken and dosed?

• Clindamycin-MIP 300 mg – adults and children over 14 years: 2 to 6 tablets daily (0.6–1.8 g clindamycin), divided into 2, 3 or 4 single doses, depending on the severity and site of infection.
• Clindamycin-MIP 600 mg – adults and children over 14 years: 3 tablets daily (1.8 g clindamycin), divided into 3 single doses. For daily doses below 1.8 g, medicines with a lower clindamycin content are used.
• Swallow the tablets whole (unchewed) with at least one large glass of water, and at least 30 minutes before lying down.
• The medicine can be taken before or after meals.
• The length of treatment depends on the disease and its course – it is decided by the doctor.

This is the dosing from the leaflet – your doctor decides the exact dose. Dosing is not transferred from one strength to the other.

Special patient groups

• Children and adolescents up to 14 years: the tablets are not suitable for children who cannot swallow a whole tablet and do not allow precise weight-based dosing – medicines with a lower clindamycin content are available. The dose is calculated by total body weight and must not exceed the adult dose.
• Impaired liver function: when taken every 8 hours, dose reduction is usually not needed; in severe impairment blood levels are monitored and the dose may be reduced or the interval extended.
• Impaired kidney function: no dose reduction in mild to moderate impairment; in severe kidney failure or anuria the doctor may reduce the dose or extend the interval from 8 to 12 hours or more.
• Haemodialysis: clindamycin is not removed by dialysis, no additional dose is needed.
• Long-term treatment (more than 10 days): blood count and liver and kidney function are checked periodically.

Contraindications – when the medicine must not be used

• allergy (hypersensitivity) to clindamycin, lincomycin (cross-allergy exists) or any of the excipients.

Warnings and precautions

• Ask your doctor if you have impaired liver function, neuromuscular disorders (myasthenia gravis, Parkinson's disease), a history of bowel disease (e.g. colitis), a tendency to allergies (atopy), allergy or asthma.
• Severe hypersensitivity and skin reactions (DRESS, Stevens-Johnson syndrome, toxic epidermal necrolysis, AGEP) have been reported – stop the medicine immediately if they occur.
• Long-term and repeated use may lead to skin and mucosal infections with resistant bacteria and fungi.
• Acute kidney problems may occur – reduced urination, swelling of the legs, shortness of breath or nausea require urgent contact with the doctor.
• Clindamycin may be an alternative for people allergic to penicillin, but isolated cases of anaphylaxis have been described in such people.
• Because of the risk of oesophageal inflammation and ulcers, take the medicine exactly as instructed (whole tablet, plenty of water, not just before bed).

Interactions with other medicines, food and drink

• Do not combine with macrolide antibiotics (e.g. erythromycin) – the effect of both medicines is reduced.
• There is cross-resistance of bacteria between clindamycin and lincomycin.
• Clindamycin may increase the effect of muscle relaxants during surgery (e.g. ether, tubocurarine, pancuronium) – inform the anaesthetist.
• Warfarin and similar blood thinners: possible increased risk of bleeding; blood clotting checks may be needed.
• Rifampicin may reduce clindamycin blood levels.
• The medicine can be taken before or after meals.

Pregnancy and breast-feeding

A large study of about 650 newborns exposed to clindamycin in the first trimester showed no increased risk of birth defects, but data are limited; clindamycin crosses the placenta, so in pregnancy it is used only after careful benefit-risk assessment. Clindamycin passes into breast milk and may cause diarrhoea, blood in the stool, rash or fungal infections in the infant – breast-feeding mothers should not take clindamycin.

Driving and using machines

Clindamycin has a minor to moderate influence on the ability to drive and use machines – some side effects (dizziness, drowsiness) may reduce concentration and reaction speed.

Possible side effects

• Very common: irritation and inflammation of the oesophagus, inflammation of the mouth lining (stomatitis), diarrhoea, abdominal pain, vomiting, nausea.
• Common: pseudomembranous colitis; blood count changes (agranulocytosis, neutropenia, thrombocytopenia, leukopenia, eosinophilia); maculopapular and measles-like rash, hives; raised liver enzymes.
• Uncommon: taste disturbance, neuromuscular blocking effect.
• Rare: drug fever, severe skin reactions (toxic epidermal necrolysis, Stevens-Johnson syndrome, angioedema, erythema multiforme), itching, vaginitis.
• Very rare: anaphylactic reaction, transient hepatitis with jaundice, polyarthritis.
• Not known: colitis caused by Clostridioides difficile, vaginal infection, anaphylactic shock, dizziness, drowsiness, headache, oesophageal ulcer, jaundice, DRESS, AGEP.

Report suspected side effects to your doctor, pharmacist or ALIMS.

Overdose, missed dose and stopping treatment

• Overdose: contact your doctor. No overdose symptoms have been observed so far; clindamycin is not removed by dialysis and there is no specific antidote.
• Missed dose: continue as usual; do not take a double dose. The medicine is safe and effective only if taken regularly.
• Stopping treatment: do not stop without consulting your doctor.

Related information

For additional care and support for the gut flora during and after antibiotic treatment, see also the Products with probiotics category – products in this category do not replace the medicine you have been prescribed.

Composition, pack and manufacturer

• Active substance: clindamycin – 300 mg (as 344 mg clindamycin hydrochloride) or 600 mg (as 688 mg clindamycin hydrochloride) per film-coated tablet.
• Excipients: macrogol 6000, microcrystalline cellulose, mannitol, crospovidone, talc, magnesium stearate, colloidal anhydrous silica, titanium dioxide (E171), basic butylated methacrylate copolymer (Eudragit E 12.5).
• Appearance: 300 mg – white round film-coated tablets; 600 mg – white oblong convex film-coated tablets with a score line on both sides.
• Pack: opaque PVC/aluminium blisters; 300 mg – 12 tablets; 600 mg – 6, 12 or 30 tablets.
• Marketing authorisation holder: MIP PHARMA D.O.O. BEOGRAD, Bulevar Mihajla Pupina 10z, New Belgrade. Manufacturer: MIP Pharma GmbH, Homburg, Germany.

Storage

• Store below 30 °C.
• Shelf life: 3 years (SmPC).
• Keep out of the sight and reach of children.

Frequently asked questions

Can I take Clindamycin-MIP if I am allergic to penicillin?

Clindamycin may be an alternative in penicillin allergy, as cross-allergy is not known, but isolated cases of anaphylaxis have been described in such people. Always tell your doctor about the allergy.

Why must I not lie down right after the tablet?

A tablet that stays in the oesophagus can cause irritation, inflammation or an ulcer. That is why it is taken with a large glass of water, at least 30 minutes before lying down.

What should I do if I get diarrhoea?

Diarrhoea is common. If it is severe, persistent, bloody or appears up to two months after treatment, contact your doctor immediately and do not take medicines that slow the bowel.

What is the difference between the 300 mg and 600 mg tablets?

300 mg tablets are taken 2–6 a day in 2–4 doses, while 600 mg tablets are taken one three times a day (1.8 g daily). Your doctor decides which strength you take and for how long.

Sources

• ALIMS – Summary of Product Characteristics Clindamycin-MIP, 300 mg and 600 mg, film-coated tablets (Serbian)
• ALIMS – Patient leaflet Clindamycin-MIP, 300 mg and 600 mg, film-coated tablets (September 2025, Serbian)

Sources checked on: 24 October 2026.