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Cefuroxim-MIP 750 mg and 1500 mg powder for solution for injection/infusion – cefuroxime, a cephalosporin antibiotic
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- Stock: Zabrana online prodaje
- Brand: CHEPHASAAR
- Model: BR-60516251
Cefuroxim-MIP is a (second-generation) cephalosporin antibiotic containing the active substance cefuroxime (as cefuroxime sodium). It is used in children and adults and works by killing the bacteria that have caused an infection.
The medicine is a powder for solution for injection/infusion in strengths of 750 mg and 1500 mg cefuroxime per vial. It is used in a healthcare facility and is usually given by a doctor or nurse – as a drip infusion, an injection into a vein or an injection into a muscle.
Important warning
- The medicine is used in a healthcare facility, under medical supervision.
- It must not be given in case of allergy to cefuroxime or other cephalosporins, or after a severe allergic reaction to penicillins, monobactams or carbapenems.
- During treatment, watch for allergic reactions, rash, diarrhoea and fungal infections.
- Report severe diarrhoea with blood and mucus, abdominal pain and fever to your doctor immediately.
- This page is for information only and is not an offer to buy the medicine online.
What is Cefuroxim-MIP (cefuroxime) used for and how is it given?
Key facts about the medicine
| Medicine name | Cefuroxim-MIP®, 750 mg and 1500 mg, powder for solution for injection/infusion |
|---|---|
| Active substance | cefuroxime (as cefuroxime sodium) |
| Strength | 750 mg or 1500 mg cefuroxime per vial |
| Pharmaceutical form | powder for solution for injection/infusion (a suspension is prepared for intramuscular injection) |
| Therapeutic group | antibacterials for systemic use – second-generation cephalosporins (ATC J01DC02) |
| Pack | carton with 10 vials (10 x 750 mg or 10 x 1500 mg) |
| Marketing authorisation holder | MIP PHARMA D.O.O. BEOGRAD (manufacturer: Chephasaar Chem.-Pharm. Fabrik GmbH, Germany) |
| ALIMS authorisation number | 750 mg: 515-01-02110-21-001; 1500 mg: 515-01-02109-21-001 – both of 10 June 2022 |
| Dispensing category (Serbia) | for use in a healthcare facility |
What is Cefuroxim-MIP used for?
Cefuroxim-MIP is used to treat infections of the:
- lungs or chest – community-acquired pneumonia and acute exacerbation of chronic bronchitis
- urinary tract – complicated infections, including pyelonephritis
- skin and soft tissue – cellulitis, erysipelas and wound infections
- abdomen (intra-abdominal infections)
It is also used to prevent infections during surgery in gastrointestinal (including oesophageal), orthopaedic, cardiovascular and gynaecological surgery, including caesarean section. In infections where anaerobic bacteria are expected it is combined with other suitable antibiotics; the doctor may request a test to identify the pathogen and its susceptibility.
How is it given and dosed?
The doctor determines the dose according to the severity and type of infection, other antibiotics, body weight, age and kidney function.
| Patient group | Usual dose from the leaflet |
|---|---|
| Newborns (0–3 weeks) | 30–100 mg/kg daily, divided into 2 or 3 doses |
| Infants older than 3 weeks and children under 40 kg | 30–100 mg/kg daily, divided into 3 or 4 doses (60 mg/kg daily is suitable for most infections) |
| Adults and adolescents of 40 kg or more | 750–1500 mg two, three or four times daily; maximum 6 g daily |
| Indication (adults and children ≥ 40 kg) | Dose according to the information for healthcare professionals |
|---|---|
| Community-acquired pneumonia, exacerbation of chronic bronchitis, soft tissue infections, intra-abdominal infections | 750 mg every 8 hours (i.v. or i.m.) |
| Complicated urinary tract infections, including pyelonephritis | 1500 mg every 8 hours (i.v. or i.m.) |
| Severe infections | 750 mg every 6 hours or 1500 mg every 8 hours (i.v.) |
| Prophylaxis – gastrointestinal, orthopaedic, gynaecological surgery (incl. caesarean section) | 1500 mg at induction of anaesthesia; additionally two doses of 750 mg i.m. may be given (after 8 and 16 hours) |
| Prophylaxis – cardiovascular and oesophageal surgery | 1500 mg at induction of anaesthesia, then 750 mg every 8 hours for the next 24 hours |
The medicine is given as an injection into a vein over 3–5 minutes, an infusion (30–60 minutes) or a deep injection into a large muscle. No more than 750 mg is given at one intramuscular site, and doses above 1.5 g are given intravenously. This is general dosing from the leaflet – the doctor determines the dose for each patient.
Special patient groups
- Impaired kidney function: with creatinine clearance of 10–20 mL/min 750 mg is given twice daily, below 10 mL/min 750 mg once daily; patients on haemodialysis receive an extra 750 mg at the end of each dialysis. Above 20 mL/min no dose reduction is needed.
- Newborns and children: the dose is calculated according to body weight (see table).
- Impaired liver function: cefuroxime is excreted mainly by the kidneys, so no effect on its pharmacokinetics is expected.
- People on a sodium-controlled diet: 750 mg: 40.65 mg (1.77 mmol) sodium per vial; 1500 mg: 83.3 mg (3.54 mmol) sodium per vial.
Contraindications – when the medicine must not be given
- allergy (hypersensitivity) to cefuroxime or any cephalosporin antibiotic
- previous severe allergic reaction to any beta-lactam antibiotic (penicillins, monobactams, carbapenems)
Warnings and precautions
- If you have had an allergic reaction to other antibiotics (e.g. penicillin), you may also be allergic to cefuroxime – tell the doctor.
- During treatment watch for allergic reactions, rash, diarrhoea and fungal infections to reduce the risk of complications.
- The medicine may affect urine or blood sugar tests and the Coombs test – tell the healthcare professional taking the sample.
- With some medicines (see interactions) the doctor may monitor kidney function.
Interactions with other medicines
- aminoglycoside antibiotics
- diuretics such as furosemide
- probenecid
- oral anticoagulants (medicines against blood clotting)
Tell your doctor about all medicines you are taking or have recently taken.
Pregnancy and breast-feeding
If you are pregnant, breast-feeding, think you may be pregnant or are planning a pregnancy, ask your doctor before treatment. The doctor will consider the benefit of treatment against the possible risk to the baby.
Driving and using machines
The medicine has no influence on the ability to drive and use machines. However, do not drive or use machines if you do not feel well.
Possible side effects
- Common (up to 1 in 10 patients): pain at the injection site, swelling and redness along the vein; in blood tests raised liver enzymes, changes in white blood cell counts (neutropenia, eosinophilia), lowered haemoglobin.
- Uncommon (up to 1 in 100): rash, itching, hives, diarrhoea, nausea, abdominal pain; in tests reduced white blood cell count, raised bilirubin, positive Coombs test.
- Frequency not known: fungal infections (Candida), overgrowth of Clostridioides difficile, fever, allergic reactions (anaphylaxis), inflammation of the large bowel with diarrhoea containing blood and mucus, inflammation of the kidneys and blood vessels, haemolytic anaemia, erythema multiforme, reduced platelet count, raised urea and creatinine.
- A small number of people may develop severe allergic or serious skin reactions (including Stevens-Johnson syndrome and toxic epidermal necrolysis); on rare occasions a fungal infection (e.g. of the mouth) may occur, more likely with longer use.
Report any suspected side effects to your doctor, nurse or ALIMS.
Overdose, missed dose and stopping treatment
- The medicine is given by a healthcare professional, so an overdose is unlikely; if you suspect you have received too much, tell the doctor.
- A missed dose is not made up with a double dose – the staff take care of the dosing schedule.
- Treatment is not stopped without the doctor’s decision.
When to seek medical help immediately?
- marked itchy rash with swelling of the face or mouth and difficulty breathing
- rash with blisters looking like small targets or widespread rash with peeling skin
- severe diarrhoea with blood and mucus, abdominal pain and fever
- white patches in the mouth or other signs of fungal infection during longer treatment
Pharmacist's advice
Cefuroxim-MIP is used in a healthcare facility. Before the first dose tell the doctor about antibiotic allergies, kidney disease and the medicines you take – especially medicines against blood clotting and diuretics.
Antibiotics can disturb the gut flora. Ask your doctor or pharmacist about using probiotics; diarrhoea with blood, mucus or abdominal pain is not for self-treatment. After discharge monitor your temperature and contact the doctor if symptoms return.
Availability and price
Cefuroxim-MIP is used in a healthcare facility; it is not dispensed in pharmacies to the public and cannot be ordered online. This page is for information only.
Related information
For additional care and support with restoring the gut flora during and after antibiotic treatment, see also the Probiotics category – products in this category do not replace the medicine you have been prescribed.
Composition, packaging and manufacturer
- Active substance: cefuroxime 750 mg or 1500 mg (as cefuroxime sodium) per vial; the medicine contains no excipients.
- Sodium: 750 mg: 40.65 mg (1.77 mmol) sodium per vial; 1500 mg: 83.3 mg (3.54 mmol) sodium per vial.
- Appearance and pack: white or almost white powder in a clear glass vial (type II) with a rubber stopper, aluminium cap and plastic flip-off lid; carton with 10 vials.
- Marketing authorisation holder: MIP PHARMA D.O.O. BEOGRAD, Ugrinovački put 3. deo 3, Belgrade. Manufacturer: Chephasaar Chem.-Pharm. Fabrik GmbH, St. Ingbert, Germany.
Storage
- Store below 25 °C in the original package to protect from light; shelf life of the unopened medicine 2 years.
- The prepared solution is chemically and physically stable for 3 hours at 25 °C or 12 hours at 5 °C; from a microbiological point of view use immediately.
- Keep out of the sight and reach of children. Return unused medicine to a pharmacy that collects unused medicines.
Frequently asked questions
Can Cefuroxim-MIP be obtained from a pharmacy?
No. The medicine is used in a healthcare facility and is given by a doctor or nurse.
What is the difference between the 750 mg and 1500 mg strengths?
Only the amount of cefuroxime per vial differs. The doctor chooses the strength and number of doses according to the infection – e.g. 750 mg every 8 hours for community-acquired pneumonia and 1500 mg every 8 hours for complicated urinary tract infections.
Can cefuroxime affect test results?
Yes – it may affect urine or blood sugar tests and the Coombs test, so tell the laboratory staff that you are receiving cefuroxime.
What if I am allergic to penicillin?
If you have had a severe allergic reaction to penicillin or other beta-lactams, you must not receive this medicine. Tell the doctor about milder reactions too before treatment.
How is cefuroxime given to children?
In children under 40 kg the dose is calculated according to body weight – 30 to 100 mg/kg daily, divided into 3 or 4 doses (in newborns into 2 or 3 doses); a dose of 60 mg/kg daily is suitable for most infections.
Sources
- ALIMS – Summary of Product Characteristics, Cefuroxim-MIP 750 mg and 1500 mg powder for solution for injection/infusion (Serbian)
- ALIMS – Package leaflet, Cefuroxim-MIP 1500 mg (June 2022, Serbian)
- ALIMS – Package leaflet, Cefuroxim-MIP 750 mg (June 2022, Serbian)
Sources checked on: 24 October 2026.
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