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Tenox 5 mg and 10 mg tablets (amlodipine) – for high blood pressure and angina pectoris
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- Stock: Zabrana online prodaje
- Brand: KRKA-EN
- Model: BR-6088519692003
Tenox is a medicine containing the active substance amlodipine (as amlodipine maleate) and belongs to the group of calcium antagonists – selective calcium channel blockers with mainly vascular effects. It is available as 5 mg and 10 mg tablets.
In high blood pressure, Tenox relaxes and widens the blood vessels so that blood passes through them more easily. In angina pectoris, it improves the blood and oxygen supply to the heart muscle and thus prevents chest pain. The medicine does not provide immediate relief of chest pain that has already started.
Important warning
- Tenox is a prescription-only medicine (regime R in Serbia); the dose is set by the doctor.
- It must not be used in severe hypotension, significant aortic stenosis, cardiogenic shock or heart failure after a heart attack.
- Do not consume grapefruit or grapefruit juice during treatment; St John's wort and some antibiotics, antifungals and HIV medicines change the effect of amlodipine.
- The medicine is taken regularly, once a day – do not stop treatment without consulting your doctor.
- This page is for information only and is not an offer to buy the medicine online. Read the official patient leaflet before use.
What is Tenox (amlodipine) used for and how should it be taken correctly?
Basic information about the medicine
| Name of the medicine | Tenox® 5 mg tablet; Tenox® 10 mg tablet |
|---|---|
| Active substance | amlodipine (as amlodipine maleate) |
| Strength | 5 mg or 10 mg amlodipine per tablet |
| Pharmaceutical form | tablet (with score line) |
| Therapeutic group | selective calcium channel blockers with mainly vascular effects (ATC C08CA01) |
| Pack | 30 tablets (3 blisters of 10) for each strength |
| Marketing authorisation holder / manufacturer | Krka-Farma d.o.o. Beograd / Krka, d.d., Novo mesto, Slovenia |
| Dispensing regime | prescription-only medicine (R) |
What is Tenox used for?
- high blood pressure (hypertension);
- chronic stable angina pectoris;
- vasospastic (Prinzmetal's) angina – a rare form of angina.
How is it used and dosed?
Tenox is taken once a day, at the same time, before or after a meal. Swallow the tablet whole with enough water or juice – but not with grapefruit juice. The tablet can be divided into two equal doses.
| Adults | usual starting dose 5 mg once daily; the dose may be increased to 10 mg once daily |
|---|---|
| Children and adolescents 6–17 years (hypertension only) | recommended starting dose 2.5 mg daily; maximum recommended dose 5 mg daily |
| Children under 6 years | use has not been studied |
It is important to take the medicine regularly; see your doctor for further prescriptions before you run out of tablets.
Special patient groups
- Children and adolescents: amlodipine is used only for high blood pressure in patients aged 6 to 17 years, at a maximum of 5 mg daily.
- Elderly: according to the summary of product characteristics, the usual dosage is used, but dose increases are made with caution.
- Kidney impairment: according to the SmPC, amlodipine is used at normal doses.
- Liver disease: inform your doctor before treatment.
Contraindications – when the medicine must not be used
- allergy to amlodipine, other calcium antagonists or any excipient (redness, rash, itching, difficulty breathing);
- severely low blood pressure (hypotension);
- clinically significant narrowing of the aortic valve (aortic stenosis) or cardiogenic shock;
- heart failure after a heart attack.
Precautions and warnings
Tell your doctor if you have or have had:
- a recent heart attack;
- heart failure;
- a severe increase in blood pressure (hypertensive crisis);
- liver disease;
- if you are elderly and your dose may need to be increased.
Interactions with other medicines, food and drink
Some medicines affect Tenox, and Tenox affects other medicines:
- ketoconazole, itraconazole (antifungals);
- ritonavir, indinavir, nelfinavir (HIV medicines);
- rifampicin, erythromycin, clarithromycin (antibiotics);
- St John's wort (Hypericum perforatum);
- verapamil, diltiazem (heart medicines);
- dantrolene (infusion for severe body temperature disorders);
- tacrolimus, sirolimus, temsirolimus, everolimus and ciclosporin;
- simvastatin (cholesterol medicine).
The blood-pressure-lowering effect is stronger if you already take other medicines for blood pressure. Grapefruit and grapefruit juice can increase amlodipine levels in the blood and cause an unpredictable drop in blood pressure.
Pregnancy and breastfeeding
The safety of amlodipine in pregnancy has not been established – if you are pregnant or planning a pregnancy, consult your doctor before starting treatment. Amlodipine passes into breast milk in small amounts; if you are breastfeeding or plan to, tell your doctor.
Driving and using machines
Tenox may affect your ability to drive or operate machines. If you feel sick, dizzy, tired or have a headache, do not drive or use machines and contact your doctor.
Possible side effects
- Very common: oedema (swelling due to fluid retention).
- Common: headache, dizziness, sleepiness (especially at the start), palpitations, flushing, abdominal pain, nausea, changed bowel habits, tiredness, weakness, visual disturbances, muscle cramps, shortness of breath, ankle swelling.
- Uncommon: mood changes, insomnia, trembling, fainting, tingling, ringing in the ears, low blood pressure, arrhythmia, cough, dry mouth, hair loss, itching, hives, urination disorders, impotence, joint and muscle pain, weight change.
- Very rare: blood count disorders, hyperglycaemia, swollen gums, gastritis, pancreatitis, hepatitis and jaundice, angioedema, severe skin reactions, sensitivity to light.
Overdose, missed dose and stopping treatment
- Overdose: too many tablets may cause a dangerous drop in blood pressure (dizziness, fainting, weakness, even shock with cold, clammy skin) – contact a doctor or the nearest hospital immediately.
- Missed dose: skip it and take the next dose at the usual time; do not take a double dose.
- Stopping treatment: keep taking the medicine until your doctor tells you to stop – symptoms may return.
When to seek medical help immediately?
- sudden wheezing, chest pain, shortness of breath or difficulty breathing;
- swelling of the eyelids, face, lips, tongue or throat;
- severe skin reactions – intense rash, redness of the whole body, blisters, peeling skin, inflamed mucous membranes;
- signs of a heart attack or heart rhythm disorder;
- severe pain in the abdomen and lower back with a general feeling of weakness (possible pancreatitis).
Pharmacist's advice
Take Tenox at the same time every day – many patients find it helpful to link the tablet to a daily routine. Measuring blood pressure at home (at rest, ideally at the same time of day) and recording the values helps your doctor assess the treatment.
Ankle swelling is common with amlodipine; if it is marked or lasts longer than a week, contact your doctor – do not stop the medicine yourself. Avoid grapefruit and ask the pharmacist before any new medicine or herbal product (especially St John's wort).
Availability and price
Tenox is a prescription-only medicine dispensed in pharmacies. ApotekaOnline.rs does not sell medicines online, and this page is for information only – please check availability at a pharmacy.
Related information
For home blood pressure monitoring during treatment, see also the category Blood pressure devices – products in this category do not replace the medicine prescribed for you.
Composition, pack and manufacturer
- active substance: amlodipine 5 mg or 10 mg per tablet, as amlodipine maleate;
- excipients: microcrystalline cellulose (E460); pregelatinised starch; sodium starch glycolate (type A); colloidal anhydrous silica; magnesium stearate (E572);
- appearance: white, round, slightly biconvex tablets with bevelled edges and a score line on one side;
- pack: carton with 3 blisters of 10 tablets (30 tablets) of 5 mg or 10 mg;
- marketing authorisation holder: Krka-Farma d.o.o. Beograd; manufacturer: Krka, d.d., Novo mesto, Slovenia;
- authorisation numbers: 515-01-03313-21-001 (5 mg) and 515-01-03314-21-001 (10 mg) of 26 May 2022.
Storage
- Keep out of the sight and reach of children.
- Store below 30 °C in the original package to protect from light and moisture.
- Do not use after the expiry date.
Frequently asked questions
When is the best time to take Tenox?
Tenox is taken once a day at the same time, before or after a meal. Swallow the tablet with water or juice, but not with grapefruit juice.
Why do my ankles swell with Tenox?
Oedema (swelling) is a very common and ankle swelling a common side effect of amlodipine. If the swelling is marked, uncomfortable or lasts more than a week, see your doctor, who will assess further treatment.
Does Tenox relieve chest pain immediately?
No. According to the leaflet, Tenox does not immediately relieve chest pain in angina; it is taken regularly to prevent attacks. For acute pain the doctor prescribes other medicines.
What if I forget to take a tablet?
Skip the missed dose and take the next one at the usual time. Do not take a double dose to make up for the missed one.
Sources
- ALIMS – Patient information leaflet Tenox 5 mg (PIL)
- ALIMS – Summary of product characteristics Tenox 5 mg (SmPC)
- ALIMS – Patient information leaflet Tenox 10 mg (PIL)
- ALIMS – Summary of product characteristics Tenox 10 mg (SmPC)
Sources checked on: 25 October 2026.
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