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ORVAGIL
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- Stock: Zabrana online prodaje
- Brand: GALENIKA-EN
- Model: BR-605754151
Orvagil 400 mg contains the active substance metronidazole. It is active against selected anaerobic bacteria and protozoa.
The medicine is prescribed for infections caused, or strongly suspected to be caused, by microorganisms susceptible to metronidazole. The dose and duration depend on the infection, age, body weight, liver function and other medicines used by the patient.
- Strength: 400 mg
- Active substance: metronidazole
- Pharmaceutical form: film-coated tablet
- Pack size: 20 film-coated tablets
- Divisibility: the tablet can be divided into equal doses
- EAN/GTIN: 8608808104160
- ATC code: P01AB01
- Route: oral use
- Age group: adults and children according to the prescribed dose
- Legal status: prescription-only medicine
- Marketing authorisation holder and manufacturer: Galenika AD Beograd, Serbia
What is Orvagil used for and how should it be taken?
Orvagil may be prescribed for:
- infections caused by anaerobic bacteria;
- septicaemia, bacteraemia, peritonitis and selected deep infections;
- pelvic and postoperative wound infections;
- prevention of selected postoperative infections;
- urogenital trichomoniasis;
- bacterial vaginosis;
- amoebiasis;
- giardiasis;
- acute ulcerative gingivitis;
- acute dental infections;
- infected leg ulcers and pressure sores involving anaerobic bacteria.
Metronidazole does not treat viral infections and should not be independently used for every digestive, vaginal, dental or urinary symptom.
Administration
- Swallow the tablet with water without chewing.
- Take it with food or immediately after food.
- Use each dose at the prescribed time.
- Complete the prescribed treatment course.
- Do not independently increase, reduce or extend treatment.
For confirmed anaerobic bacterial infections, the official information describes an initial adult dose of 800 mg followed by 400 mg every eight hours. Treatment commonly lasts approximately seven days, but the regimen differs significantly for trichomoniasis, bacterial vaginosis, amoebiasis, giardiasis and dental infections.
This information is not a self-dosing guide. The doctor determines the appropriate regimen.
Children require weight- and age-adjusted dosing. A different strength or pharmaceutical form may be required for accurate administration.
If a dose is missed, take it when remembered unless the next dose is near. Do not take a double dose.
Avoid alcohol during treatment and for at least 48 hours after the final dose.
Combining metronidazole with alcohol may cause nausea, vomiting, abdominal pain, flushing, headache, sweating and palpitations.
Check whether liquid medicines, drops or tinctures contain alcohol.
Stop treatment and contact a doctor immediately if tingling, burning, numbness or weakness of the limbs, impaired coordination, confusion, hallucinations or seizures occur.
Prolonged or repeated treatment requires particular caution. Blood tests may be required when treatment lasts longer than ten days.
Patients with Cockayne syndrome have an increased risk of severe liver injury and require specialist monitoring.
Do not take Orvagil:
- if you are allergic to metronidazole;
- if you are allergic to tinidazole or another nitroimidazole;
- if you are allergic to another tablet ingredient.
Tell the doctor about liver disease, kidney disease or dialysis, epilepsy, another neurological condition, a previous blood disorder or a previous serious reaction to metronidazole.
Important interactions
Tell the doctor if you use warfarin or another oral anticoagulant, lithium, phenytoin, phenobarbital, disulfiram, busulfan, ciclosporin, fluorouracil or medicines that affect cardiac rhythm.
Metronidazole may increase the anticoagulant effect of warfarin. Its combination with lithium may increase lithium levels and kidney toxicity. Concomitant disulfiram use may cause confusion or psychotic reactions.
Pregnancy and breastfeeding
Orvagil should be used during pregnancy only when the doctor considers treatment necessary.
Metronidazole passes into breast milk. Treatment during breastfeeding should generally be avoided or temporary interruption of breastfeeding should be discussed with the doctor.
Possible side effects
- nausea, vomiting and abdominal discomfort;
- diarrhoea and reduced appetite;
- an unpleasant or metallic taste;
- coated tongue;
- headache and dizziness;
- drowsiness;
- rash and itching;
- dark urine;
- muscle or joint pain.
- swelling of the face, lips, tongue or throat;
- difficulty breathing or swallowing;
- a widespread rash, blistering, mucosal sores or peeling skin;
- yellowing of the skin or eyes;
- severe abdominal pain radiating to the back;
- tingling, numbness or weakness of the limbs;
- confusion, hallucinations, seizures or loss of consciousness;
- a stiff neck with severe headache and sensitivity to light;
- unusual bruising, bleeding gums or recurrent infections;
- sudden changes in vision or hearing.
Storage
- Store in the original packaging, protected from light and moisture.
- No special temperature conditions are required.
- Keep out of the sight and reach of children.
- Do not use after the expiry date.
Composition: each film-coated tablet contains 400 mg metronidazole.
Take Orvagil with or immediately after food and a glass of water. This may reduce nausea and abdominal discomfort.
Do not stop treatment as soon as symptoms improve. Premature discontinuation may result in incomplete treatment and recurrence.
Avoid alcohol during treatment and for at least 48 hours after the final tablet.
When using a bacterial probiotic, an interval of at least two hours from the antibiotic is commonly recommended. Follow the instructions for the particular product.
Orvagil is available only on prescription. Current availability and price should be checked directly with a pharmacy. This information page does not constitute an offer for online sale.
Explore the diarrhoea after antibiotics and intestinal microbiota support category.
Probiotics do not treat an anaerobic or protozoal infection and do not replace Orvagil.
Related products for intestinal microbiota support:
- LACTIBIANE ATB – 10 CAPSULES
- MEDICOBIOTIC PROBIOTIC – 10 CAPSULES
- PROLIFE – 20 CAPSULES
- BULARDI PLUS CAPSULES
Official sources:
Content reviewed on 2 August 2026.
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For all orders received up to 12h from Monday to Friday, the approximate delivery time is 2-4 business days for the whole territory of the Republic of Serbia. In case the order is placed on weekends (Saturdays and Sundays), the delivery is done as well as for the orders received on Monday - so next business day.
Deliveries are not made on Saturdays and Sundays.
Additional information
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Shipping cost
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For goods ordered up to 5.000,00 RSD, delivery charge is 260.00 RSD (VAT included). For goods over 5.000,00 RSD, shipping is free of charge.
For international delivery:
For the export of goods abroad through the PostExport service of Post of Serbia, the shipping price is for:
- Zone I (Slovenia, Croatia, Bosnia and Herzegovina, Montenegro, Northern Macedonia) - 1,280.00 RSD
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- Zone III (Asia, Africa, America, Australia and other countries) - 2,650.00 RSD
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