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NEXIUM
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- Stock: Zabrana online prodaje
- Brand: ASTRA ZENECA
- Model: BR-605667564150
Nexium 20 mg and 40 mg contains esomeprazole, a proton-pump inhibitor that reduces the amount of acid produced by the stomach.
It is prescribed for gastro-oesophageal reflux disease – GERD, erosive reflux oesophagitis, ulcers associated with Helicobacter pylori, ulcers caused by non-steroidal anti-inflammatory medicines and other conditions involving excessive gastric-acid secretion.
Registered packs contain 7 or 14 gastro-resistant tablets in strengths of 20 mg or 40 mg. The medicine is prescription only in Serbia.
Esomeprazole may relieve symptoms of a more serious stomach or oesophageal condition and delay diagnosis.
Contact a doctor promptly for unexplained weight loss, difficulty swallowing, persistent vomiting, vomiting blood, severe abdominal pain or black stools.
Nexium – indications, dosage and precautions
Approved uses
- treatment of erosive reflux oesophagitis;
- long-term prevention of relapse after the oesophagus has healed;
- symptomatic treatment of GERD;
- eradication of Helicobacter pylori together with prescribed antibiotics;
- treatment and prevention of ulcers associated with NSAID therapy;
- extended treatment after intravenous prevention of recurrent peptic-ulcer bleeding;
- Zollinger–Ellison syndrome and other conditions involving excessive gastric-acid secretion.
In adolescents aged 12 years and over, the tablets are used for GERD and, under specialist supervision, as part of antibiotic treatment for an H. pylori-associated duodenal ulcer.
Common adult dosage schedules
- Erosive reflux oesophagitis: 40 mg once daily for 4 weeks; a further 4 weeks may be prescribed.
- Prevention of relapse: 20 mg once daily.
- Symptomatic GERD without oesophagitis: 20 mg once daily.
- On-demand GERD treatment: up to 20 mg once daily when approved by the doctor.
- H. pylori treatment: 20 mg twice daily together with prescribed antibiotics, commonly for 7 days.
- NSAID-associated gastric ulcer: 20 mg once daily for 4–8 weeks.
- Prevention of NSAID-associated ulcers: 20 mg once daily in patients at risk.
- After intravenous prevention of recurrent bleeding: 40 mg once daily for 4 weeks.
- Zollinger–Ellison syndrome: an initial dose of 40 mg twice daily, followed by individual dose adjustment.
The strength, duration and number of daily doses must not be changed without medical advice.
How to take Nexium
- It may be taken with food or on an empty stomach.
- Swallow the tablet whole with sufficient water.
- Do not chew, crush or grind the tablet.
For swallowing difficulties, disperse the tablet in approximately half a glass of still water. Stir until the tablet breaks apart and drink the liquid with the pellets immediately or within 30 minutes.
Rinse the glass with more water and drink it. Do not chew or crush the pellets and do not use milk, juice or carbonated water.
Do not use Nexium
- if allergic to esomeprazole or an excipient;
- if allergic to another proton-pump inhibitor;
- together with nelfinavir.
Long-term treatment
Patients receiving long-term treatment, particularly for more than one year, require regular medical review.
Long-term acid suppression may be associated with reduced vitamin B12 absorption, low blood magnesium, a small increase in fracture risk and a slightly increased risk of certain gastrointestinal infections.
Important interactions
Tell the prescriber about nelfinavir, atazanavir, clopidogrel, warfarin, digoxin, phenytoin, diazepam, cilostazol, tacrolimus, methotrexate, rifampicin, St John’s wort, azole antifungals and medicines whose absorption depends on gastric acidity.
Pregnancy and breastfeeding
Use during pregnancy requires an individual medical assessment. The current Serbian leaflet advises against use while breastfeeding.
Possible side effects
Common effects include headache, abdominal pain, diarrhoea, constipation, flatulence, nausea and vomiting.
Other effects may include dizziness, sleep disturbance, dry mouth, rash, itching, ankle swelling and changes in liver-test results.
- swelling of the face, lips, tongue or throat;
- difficulty breathing or swallowing;
- fainting or a serious allergic reaction;
- a widespread rash, blisters, mucosal sores or peeling skin;
- yellow skin or eyes and dark urine;
- vomiting blood or black stools;
- markedly reduced urination or severe flank pain.
Pack details
| Pack | EAN | JKL |
|---|---|---|
| 20 mg, 7 tablets | 8606103714435 | 1122810 |
| 20 mg, 14 tablets | 8606103714459 | 1122815 |
| 40 mg, 7 tablets | 8606103714442 | 1122811 |
| 40 mg, 14 tablets | 8606103714466 | 1122814 |
- ATC code: A02BC05.
- Authorisation holder: EVROPA LEK PHARMA D.O.O. BEOGRAD.
- Supply status: prescription only.
- Storage: below 30°C in the original pack, protected from moisture.
Nexium is a prescription-only medicine and cannot be ordered through the online shop. Check the availability and price of the prescribed strength and pack directly with a pharmacy.
Nexium is not an antacid that immediately neutralises acid already present in the stomach. It reduces the production of new acid and should be taken regularly according to the prescribed schedule.
Do not crush or chew the tablet. Persistent symptoms despite regular treatment require a review of administration, interactions and possible warning symptoms rather than an independent dose increase.
Ljubica Barbulović, Master of Pharmacy
Related category and guide
What causes stomach acid and how can it be soothed?
Related non-prescription products include GERBEX 20 sachets, REFALGIN TABLETS and SALVIT ACIDORELIEF CHEW.
Important: these products are not direct substitutes for prescribed Nexium and should not be added automatically without checking their composition and administration schedule.
Is Nexium available without a prescription?
No. The registered tablets are prescription only in Serbia.
Can the tablet be crushed?
No. It may be dispersed in still water, but the pellets must not be chewed or crushed.
Can it be taken with food?
Yes. It may be taken with food or on an empty stomach.
Can children use it?
This tablet form is intended for approved indications in patients aged 12 years and over.
When is urgent assessment required?
For vomiting blood, black stools, difficulty swallowing, a severe allergic reaction, a serious rash or unexplained weight loss.
Sources: official patient leaflet, Summary of Product Characteristics and packaging text approved by ALIMS.
Official Nexium patient leaflet |
Summary of Product Characteristics
Leaflet revision: November 2023. Authorisation transfer: March 2024. Sources checked: 4 August 2026.
Pharmacy Online has a contract with the Daily Express courier service and it is delivered on the territory of the Republic of Serbia through this service. Exports of goods to foreign countries are done through DHL and PostExport.
For all orders received up to 12h from Monday to Friday, the approximate delivery time is 2-4 business days for the whole territory of the Republic of Serbia. In case the order is placed on weekends (Saturdays and Sundays), the delivery is done as well as for the orders received on Monday - so next business day.
Deliveries are not made on Saturdays and Sundays.
Additional information
The items will be packed so that they cannot be damaged by normal handling of the goods in transit. When picking up the product, the buyer is obliged to check for any damage and immediately advertise it to the courier who delivered the goods, or refuse to take over the shipment, which shows the external damage. Any subsequent product claims for shipping damage will not be considered.
When picking up the product, the customer is required to sign the delivery note taken by the Daily Express delivery worker. The delivery note is considered to be a receipt and delivery note.
The courier service delivers the goods to the address, ie. does not bring into the living space.
Delivery restrictions on goods
Delivery of items purchased on the site www.apotekaonline.rs is made exclusively through the Daily Express courier service in the territory of the Republic of Serbia. Delivery outside the territory of the Republic of Serbia, ie export of goods, is done exclusively through the service of DHL and PostExport Post of Serbia.
Shipping cost
For the territory of the Republic of Serbia:
For goods ordered up to 5.000,00 RSD, delivery charge is 260.00 RSD (VAT included). For goods over 5.000,00 RSD, shipping is free of charge.
For international delivery:
For the export of goods abroad through the PostExport service of Post of Serbia, the shipping price is for:
- Zone I (Slovenia, Croatia, Bosnia and Herzegovina, Montenegro, Northern Macedonia) - 1,280.00 RSD
- Zone II (Other European countries) - 1,790.00 RSD
- Zone III (Asia, Africa, America, Australia and other countries) - 2,650.00 RSD
Delivery time is 15 days or more (depending on the country of delivery)
For export of goods abroad through DHL service, the shipping price is 2,700.00 RSD. Delivery time is 1-5 business days (depending on the country of delivery)
Shipping cost is with tax. The price includes the delivery of the parcel to the buyer's address with the associated tax and customs at the seller's expense. A possible additional cost may be a customs charge against the buyer, depending on the country to which the package is being shipped.
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