Lanzul 30 mg gastro-resistant capsules – lansoprazole for ulcers, reflux and heartburn

Lanzul contains lansoprazole, a medicine from the group of proton pump inhibitors. Proton pump inhibitors reduce the secretion of stomach acid and thus relieve complaints in conditions where acid is increased or damages the lining of the stomach, duodenum and oesophagus.

One gastro-resistant hard capsule contains 30 mg lansoprazole. The medicine is intended for adults. The same substance is also available as 15 mg (Lanzul S 15 mg) – the doctor prescribes the dose according to the disease; dosing is not automatically transferred from one strength to another.

What is Lanzul 30 mg used for and how should it be taken?

Key facts about the medicine

What is Lanzul used for?

• treatment of gastric and duodenal ulcers;
• treatment of inflammation of the oesophagus (reflux oesophagitis) and long-term prevention of reflux oesophagitis;
• relief of heartburn and acid regurgitation (symptomatic gastro-oesophageal reflux disease);
• treatment of indigestion with increased acidity (hyperacidic dyspepsia);
• treatment of Helicobacter pylori infection in combination with antibiotics;
• treatment or prevention of gastric or duodenal ulcers in patients who need continuous treatment with non-steroidal anti-inflammatory drugs (NSAIDs);
• treatment of Zollinger-Ellison syndrome.
• If you do not feel better or feel worse after 14 days of treatment, contact your doctor.

How is Lanzul taken?

• Swallow the capsules whole with a little water; neither the capsules nor their contents may be crushed or chewed. Take the medicine at least 30 minutes before a meal.
• With once-daily dosing take it at the same time every day, preferably in the morning before breakfast; with twice-daily dosing – in the morning before breakfast and in the evening.

• Indication (adults)	Usual dose according to the leaflet
  Heartburn and acid regurgitation	15 mg or 30 mg once daily for 4 weeks; if symptoms persist after 4 weeks – see a doctor
  Duodenal ulcer	30 mg once daily for 2 weeks
  Gastric ulcer	30 mg once daily for 4 weeks
  Reflux oesophagitis	30 mg once daily for 4 weeks
  Long-term prevention of reflux oesophagitis	15 mg once daily; the doctor may increase to 30 mg
  H. pylori infection	30 mg twice daily with two antibiotics (clarithromycin + amoxicillin or clarithromycin + metronidazole), usually for 7 days
  Ulcer during continuous NSAID treatment	30 mg once daily for 4 weeks
  Prevention of ulcers during NSAID treatment	15 mg once daily; the doctor may prescribe 30 mg
  Zollinger-Ellison syndrome	initially 60 mg (two 30 mg capsules) once daily, then adjusted to response

• The doses in the table refer to lansoprazole in general; some are achieved with the 15 mg capsule and others with the 30 mg capsule. The exact strength, dose and duration are decided by the doctor.

Special patient groups

• Children and adolescents: the medicine should not be used.
• Elderly: because of slower elimination the dose is adjusted individually; no more than 30 mg daily should be given unless there are compelling clinical reasons (SmPC).
• Liver impairment: in moderate to severe liver disease medical supervision is needed and a 50% reduction of the daily dose is recommended (SmPC).
• Kidney impairment: no dose adjustment is needed.

Contraindications – when the medicine must not be used

• allergy (hypersensitivity) to lansoprazole or to any of the excipients.

Warnings and precautions

• Tell your doctor if you have ever had a skin reaction to similar acid-reducing medicines; a rash, especially on sun-exposed skin, with joint pain may require stopping treatment.
• The doctor may perform an endoscopy to make the diagnosis and exclude a malignant disease.
• The medicine is associated with a small increase in infectious diarrhoea – contact your doctor immediately if diarrhoea occurs.
• With use for more than one year: medical check-ups, including blood magnesium; moderately increased risk of hip, wrist or spine fractures (caution in osteoporosis and with corticosteroids); possible vitamin B12 deficiency.
• Tell your doctor that you are taking the medicine before a chromogranin A blood test.
• The medicine contains sucrose – if you have an intolerance to some sugars, consult your doctor.

Interactions with other medicines, food and drink

• HIV protease inhibitors (atazanavir, nelfinavir) – concomitant use is not recommended;
• methotrexate;
• ketoconazole, itraconazole, rifampicin;
• digoxin;
• warfarin;
• theophylline;
• tacrolimus;
• fluvoxamine;
• antacids and sucralfate;
• St John’s wort (Hypericum perforatum).

Pregnancy and breast-feeding

• Because safety data are insufficient, use during pregnancy and breast-feeding is not recommended. If you are pregnant, breast-feeding or planning a pregnancy, ask your doctor before taking the medicine.

Driving and using machines

• Dizziness, vertigo and visual disturbances may occasionally occur. If you experience them, do not drive or operate machinery.

Possible side effects

• Common: headache, dizziness, nausea, vomiting, diarrhoea, stomach pain, constipation, flatulence, dry mouth or throat, benign stomach polyps, increased liver function test values, rash (hives), itching, tiredness.
• Uncommon: changes in blood cell counts, depression, muscle and joint pain, hip, wrist or spine fractures, fluid retention (swelling).
• Rare: anaemia, insomnia, restlessness, drowsiness, confusion, hallucinations, visual disturbances, vertigo, tingling, tremor, taste disturbance, loss of appetite, inflamed tongue, candidiasis, pancreatitis, hepatitis (yellowing of the skin or eyes), skin reactions, hair loss, sensitivity to light, kidney problems, breast enlargement in men, impotence, fever, angioedema.
• Very rare: agranulocytosis and pancytopenia, colitis, stomatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis, severe hypersensitivity including shock, low sodium, increased cholesterol and triglycerides.
• Not known: low blood magnesium (after more than three months of treatment), visual hallucinations, subacute cutaneous lupus erythematosus.

Overdose, missed dose and stopping treatment

• Overdose: if you have taken more medicine than you should, seek medical help immediately.
• Missed dose: take it as soon as you remember unless it is almost time for the next dose – then skip the missed dose. Do not take a double dose.
• Stopping treatment: do not stop early because symptoms have improved – the condition may not be fully healed and complaints may return.

Related information

For additional care and support with heartburn and stomach complaints, see also the category Heartburn (excess acid) – products in this category do not replace the medicine you have been prescribed.

Composition, pack and manufacturer

• Active substance: lansoprazole 30 mg per gastro-resistant hard capsule.
• Excipients in the pellets: sugar spheres, hydroxypropylcellulose (E463), heavy magnesium carbonate (E504), sucrose, maize starch, sodium laurilsulfate, hypromellose (E464), methacrylic acid – ethyl acrylate copolymer (1:1) dispersion 30%, talc (E553b), macrogol 6000, titanium dioxide (E171).
• Capsule shell: gelatin, titanium dioxide (E171).
• Appearance: white hard gelatin capsules filled with white to light brown or pinkish pellets.
• Pack: 14 capsules (2 blisters of 7) (PVC/PE/PVDC-Al blister).
• Marketing authorisation holder: Krka-Farma d.o.o. Belgrade; manufacturer: Krka d.d., Novo Mesto, Slovenia.
• Authorisation number: 515-01-05071-19-002 of 14.01.2021 (renewal).

Storage

• Store below 25 °C, in the original package in order to protect from moisture.
• Keep out of the sight and reach of children; do not use after the expiry date.
• Return unused medicine to a pharmacy that collects unused medicines.

Frequently asked questions

When is the best time to take Lanzul?

At least 30 minutes before a meal; with once-daily dosing preferably in the morning before breakfast, always at the same time. Swallow the capsule whole with a little water; do not chew or crush it.

What is the difference between Lanzul S 15 mg and Lanzul 30 mg?

Both contain lansoprazole and differ in strength. According to the leaflet, 15 mg is mostly used for long-term prevention of reflux oesophagitis and prevention of ulcers during NSAID treatment, and 30 mg for treating ulcers, oesophagitis and H. pylori infection. For heartburn 15 or 30 mg is used – the doctor decides the strength.

How long is Lanzul taken?

It depends on the disease: e.g. duodenal ulcer 2 weeks, gastric ulcer and reflux oesophagitis 4 weeks, H. pylori eradication usually 7 days, while prevention may last longer. If complaints persist for more than 14 days despite treatment, contact your doctor.

Can I take antacids or St John’s wort with Lanzul?

The leaflet lists antacids, sucralfate and St John’s wort among the substances that interact with lansoprazole. Ask your doctor or pharmacist about concomitant use and spacing; avoid St John’s wort without medical advice.

Sources

• ALIMS – Package leaflet Lanzul 30 mg gastro-resistant capsules (PIL, Serbian)
• ALIMS – Summary of product characteristics Lanzul 30 mg (SmPC, Serbian)

Date sources were checked: 25.10.2026.