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Defrinol tablets 30 mg + 200 mg (pseudoephedrine, ibuprofen) – colds and flu with blocked nose and sinuses
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- Stock: Zabrana online prodaje
- Brand: GALENIKA-EN
- Model: BR-561
Defrinol tablets are a combination medicine for cold and flu symptoms. Each film-coated tablet contains 30 mg of pseudoephedrine hydrochloride and 200 mg of ibuprofen. Ibuprofen belongs to the non-steroidal anti-inflammatory drugs (NSAIDs) and relieves pain, lowers fever and reduces signs of inflammation, while pseudoephedrine is a decongestant that helps to clear a blocked nose and sinuses so that breathing through the nose becomes easier.
According to the official package leaflet, Defrinol is intended for adults and adolescents over 12 years with colds and flu when a blocked nose and sinuses are accompanied by headache, sore throat, muscle aches and/or fever. It should not be taken if only one of these symptoms is present. In Serbia it is available without a prescription, but because of pseudoephedrine and ibuprofen it has a number of restrictions that should be checked before the first tablet.
Important warning
- Supply status in Serbia: available without a medical prescription (OTC).
- Do not use under 12 years of age, during pregnancy or breastfeeding, with high blood pressure, heart disease, diabetes, glaucoma, thyroid or prostate disease, or together with other NSAIDs, painkillers or decongestants.
- No more than 6 tablets a day, at least 4 to 6 hours apart; if you do not feel better after 3 days, see a doctor.
- Pseudoephedrine may give a positive anti-doping test.
- This page is for information only and is not an offer to buy the medicine online.
When are Defrinol tablets used for a cold and how should they be taken correctly?
Key facts about the medicine
| Name of the medicine | Defrinol®, 30 mg + 200 mg, film-coated tablets |
|---|---|
| Active substance | pseudoephedrine hydrochloride and ibuprofen |
| Strength | 30 mg pseudoephedrine hydrochloride + 200 mg ibuprofen per film-coated tablet |
| Pharmaceutical form | film-coated tablet for oral use (round, biconvex, red) |
| Therapeutic group | nasal decongestants for systemic use, sympathomimetics in combination (ATC R01BA52) |
| Pack | 20 film-coated tablets (2 blisters of 10 tablets) |
| Marketing authorisation holder | GALENIKA AD BEOGRAD (marketing authorisation holder and manufacturer) |
| Supply status (Serbia) | available without a medical prescription |
What is Defrinol used for?
According to the package leaflet, Defrinol relieves symptoms of colds and flu with congestion of the nose and sinuses accompanied by:
- headache;
- sore throat;
- muscle aches;
- raised body temperature (fever).
The medicine is intended for adults and adolescents over 12 years. Use it only when you have a blocked nose and sinuses together with headache, pain and/or fever – it is not intended when only one symptom is present (e.g. only a headache or only a blocked nose). Defrinol relieves the symptoms but does not treat the cause of a cold or flu.
How is it used and dosed?
The medicine is taken by mouth and only for a short time. The lowest effective dose should be used for the shortest period needed to relieve symptoms.
| Group | Dosing according to the leaflet |
|---|---|
| Adults, elderly and children over 12 years | 1–2 tablets every 4 to 6 hours, if necessary |
| Maximum daily dose | no more than 6 tablets a day |
| Interval between doses | at least 4 to 6 hours |
| Children under 12 years | must not be given |
- Take the tablets with enough water; food and drink do not affect the action of the medicine.
- If symptoms last longer than 3 days, consult a doctor.
- If you have an infection and fever and pain persist or get worse, see a doctor without delay – the medicine may mask signs of infection.
- Do not exceed the stated dose and duration; the risk of heart attack and stroke with ibuprofen increases with higher doses and longer treatment.
Special patient groups
- Children under 12 years: the medicine is not used.
- Adolescents aged 12 to 17: if dehydrated (not drinking fluids or having lost fluids through prolonged vomiting or diarrhoea) there is a risk of kidney damage – ask a doctor before use.
- Elderly: the dose is the same as for adults, but side effects such as stomach bleeding or perforation are more frequent and can be dangerous.
- Severe kidney or liver disease: the medicine must not be used.
Contraindications – when the medicine must not be used
Defrinol must not be taken:
- if you are allergic or have previously had a hypersensitivity reaction (rash, hives, itching, breathing difficulties, chest tightness, swelling of the mouth, face, lips or tongue) to ibuprofen, aspirin, other NSAIDs or any ingredient of the medicine;
- if you have or have had a stomach ulcer, perforation or bleeding from the stomach;
- if you have diabetes, prostate problems, thyroid disease, glaucoma or phaeochromocytoma (a tumour of the adrenal gland);
- if you have severe kidney or liver disease, heart disease, severe heart failure, high blood pressure or circulatory disorders (angina pectoris);
- if you are taking or have taken MAO inhibitors in the last 14 days, or are taking tricyclic antidepressants;
- if you have other bleeding problems or have had a stroke in the past;
- together with other NSAIDs, painkillers or decongestants;
- in children under 12 years, during pregnancy and breastfeeding.
Precautions and warnings
- Talk to a doctor or pharmacist before use if you have heart problems, peripheral arterial disease, have had a heart attack, bypass surgery or any type of stroke (including a "mini-stroke" – TIA), and in case of high blood pressure, diabetes, high cholesterol, smoking or heart disease and stroke in the family.
- Caution is needed with bleeding disorders, stomach ulcer or inflammatory bowel disease (ulcerative colitis, Crohn's disease), asthma or allergies, heart, kidney, liver or prostate disease and systemic lupus erythematosus (SLE).
- Sudden abdominal pain or rectal bleeding may be a sign of ischaemic colitis – stop taking the medicine and see a doctor immediately.
- If a rash, mucosal lesions, blisters or other signs of hypersensitivity appear, stop treatment and see a doctor immediately – these may be signs of a serious skin reaction.
- Sudden loss or reduction of vision (spots in the visual field) may indicate reduced blood flow to the optic nerve – stop using the medicine and see a doctor immediately.
- Ibuprofen should be avoided during chickenpox; the medicine may mask symptoms of an infection and delay its treatment.
- Alcohol should be avoided during treatment. If you need anaesthesia, stop taking the medicine and inform the anaesthetist.
- Pseudoephedrine hydrochloride may cause a positive result in anti-doping tests.
Interactions with other medicines, alcohol and food
Defrinol must not be taken together with other NSAIDs, nasal or oral decongestants, MAO inhibitors (and for 2 weeks after them) or tricyclic antidepressants. Tell your doctor or pharmacist if you are taking:
- medicines that prevent blood clotting (warfarin, ticlopidine, aspirin/acetylsalicylic acid) and heparin;
- medicines for high blood pressure (ACE inhibitors such as captopril, beta blockers such as atenolol, angiotensin II antagonists such as losartan) and diuretics, including potassium-sparing diuretics;
- guanethidine, reserpine or methyldopa;
- digoxin or quinidine, phenytoin, lithium, methotrexate, ciclosporin, tacrolimus;
- corticosteroids, SSRI antidepressants (e.g. fluoxetine), quinolone antibiotics, aminoglycosides (gentamicin, amikacin), zidovudine, mifepristone;
- antacids, sulfonylureas (glibenclamide), sulfinpyrazone and probenecid;
- ergot derivatives (for migraine), dopamine receptor agonists (for Parkinson's disease);
- preparations containing ginkgo biloba.
Food and drink do not affect the action of the medicine. Alcohol should be avoided during treatment.
Pregnancy and breastfeeding
Defrinol must not be taken during pregnancy or breastfeeding. As an NSAID, ibuprofen may temporarily reduce female fertility; the effect disappears after stopping treatment. If you are planning a pregnancy or have difficulty getting pregnant, tell your doctor before use.
Driving and using machines
When taken at the recommended dose, Defrinol has no or negligible influence on the ability to drive and use machines. Some people may experience dizziness, hallucinations, unusual headaches, visual or hearing disturbances – in that case do not drive or operate machines.
Possible side effects
If any of the serious side effects occur, stop taking the medicine and contact your doctor or pharmacist:
| Frequency | Serious side effects (stop the medicine) |
|---|---|
| Common | bleeding from the stomach or intestine (vomiting blood, blood in the stool, black tarry stool), minor blood loss that rarely leads to anaemia |
| Uncommon | severe headaches or headaches worse than usual |
| Very rare | heart attack, fast heartbeat or palpitations, allergic reactions and anaphylactic shock, skin or mucosal damage with blisters, severe skin infections during chickenpox |
| Not known | stroke, agitation and nervousness, acute generalised exanthematous pustulosis, ischaemic colitis, ischaemic optic neuropathy, difficulty passing urine in men with prostate problems |
Other possible side effects:
- common: indigestion, abdominal pain, nausea, vomiting, diarrhoea, constipation, wind, loss of appetite;
- uncommon: stomach ulcer, pain or inflammation of the mouth lining, insomnia, drowsiness or tiredness, agitation, dizziness, visual disturbances, rash and itching, asthma attacks in hypersensitive people;
- rare: kidney disorders, increased uric acid, ringing in the ears, worsening of asthma;
- very rare: depression, heart or kidney failure, high blood pressure, pancreatitis, aseptic meningitis, blood cell disorders, liver disorders;
- not known: chest pain, dry mouth and thirst, cramps and convulsions, hallucinations, skin sensitivity to light, DRESS syndrome.
Overdose, missed dose and stopping treatment
- Overdose: contact a doctor or hospital immediately and take the remaining tablets with you. Possible symptoms include nausea, abdominal pain, vomiting (sometimes with blood), headache, ringing in the ears, confusion, uncontrolled eye movements; at very high doses drowsiness, chest pain, palpitations, loss of consciousness and convulsions.
- Missed dose: take the next dose at the usual time; never take a double dose.
- Stopping: the medicine is used only while symptoms last. If cold or flu symptoms do not improve, get worse or new ones appear, consult a doctor.
When to seek medical help immediately?
- vomiting blood, blood in the stool or black, tarry stool;
- swelling of the face, lips, tongue or throat, difficulty breathing or chest tightness;
- chest pain, fast or irregular heartbeat;
- sudden weakness on one side of the body, speech disturbance or severe headache (signs of stroke);
- sudden abdominal pain or rectal bleeding;
- sudden loss or reduction of vision;
- widespread rash with blisters, peeling skin or pustules and fever.
Pharmacist's advice
Defrinol makes sense only when a blocked nose/sinuses and pain or fever are present at the same time. For a single symptom it is better to choose a product with one active substance – this way you avoid unnecessary intake of pseudoephedrine or ibuprofen.
Before buying, check your blood pressure and the medicines you already use: the most common mistake is using Defrinol together with another cold remedy, painkiller or nasal drops/spray containing a decongestant. To rinse the nose while taking Defrinol you can use saline or sea-water sprays without a decongestant.
Watch the total daily dose (no more than 6 tablets) and do not use the medicine for more than 3 days without talking to a doctor. Athletes should keep in mind that pseudoephedrine may give a positive anti-doping test.
Availability and price
Defrinol 30 mg + 200 mg film-coated tablets are available without a prescription. Please check current availability and price directly at the pharmacy.
This page is for information only and is not an offer to buy the medicine online.
Composition, packaging and manufacturer
- Active substances: 30 mg pseudoephedrine hydrochloride and 200 mg ibuprofen per film-coated tablet.
- Tablet core: calcium hydrogen phosphate dihydrate; maize starch; sodium starch glycolate (type A); hypromellose; magnesium stearate.
- Film coating: hypromellose; macrogol 6000; talc; titanium dioxide (E171); Ponceau 4R lake 22% (E124), which may cause an allergic reaction.
- Pack: 2 blisters (ALU/PVC) of 10 film-coated tablets, 20 tablets in total.
- Marketing authorisation holder and manufacturer: GALENIKA AD BEOGRAD, Batajnički drum b.b., Belgrade. Authorisation 515-01-04276-21-001 of 18 October 2022.
Storage
- Keep out of the sight and reach of children.
- Store below 25 °C in the original package.
- Do not use after the expiry date stated on the carton.
- Return unused medicine to a pharmacy that collects unused medicines from the public; do not throw it into wastewater or household waste.
Frequently asked questions
Can I take Defrinol with paracetamol or another cold medicine?
Defrinol must not be combined with other NSAIDs, painkillers or decongestants. Many combination cold remedies contain exactly these substances, so ask a pharmacist or doctor before any combination.
How many Defrinol tablets may I take a day and for how long?
Adults and children over 12 years take 1–2 tablets every 4 to 6 hours, no more than 6 tablets a day. If you do not feel better after 3 days, see a doctor.
Can I take Defrinol if I have high blood pressure or diabetes?
No. High blood pressure, heart disease, diabetes, glaucoma, thyroid and prostate disease are contraindications for this medicine.
Is Defrinol the same as Defrinol forte?
No. Defrinol forte is a separate medicine with a higher content of active substances (60 mg pseudoephedrine and 400 mg ibuprofen) and its own leaflet. The dosing on this page applies only to Defrinol 30 mg + 200 mg tablets.
Related information
For additional care and support with colds and flu, see also the Colds and flu category – products in this category do not replace the medicine you have been prescribed.
Sources
- ALIMS – Package leaflet for Defrinol, 30 mg + 200 mg, film-coated tablets (PDF, Serbian)
- ALIMS – Summary of product characteristics for Defrinol, 30 mg + 200 mg, film-coated tablets (PDF, Serbian)
Sources checked on: 23 October 2026.
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