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Trasolette 1 mg film-coated tablets (anastrozole) – for hormone receptor-positive breast cancer after menopause
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- Stock: Zabrana online prodaje
- Brand: PHARMA SWISS
- Model: BR-6051989362003
Trasolette is a medicine containing anastrozole, an active substance from the group of aromatase inhibitors. Anastrozole blocks the enzyme aromatase and thereby lowers the level of oestrogen, the female sex hormone produced by the body.
The medicine is used to treat breast cancer in postmenopausal women. In Serbia it is registered as 1 mg film-coated tablets in a pack of 28 tablets. Treatment is long-term and is carried out under the supervision of an oncologist.
Important warning
- Supply status: the medicine is available on prescription.
- The medicine is intended only for postmenopausal women; it must not be taken during pregnancy or breastfeeding.
- Anastrozole reduces bone mineral density – the doctor assesses the risk of osteoporosis and fractures and monitors bone density if needed.
- Do not take tamoxifen or oestrogen-containing medicines (e.g. hormone replacement therapy) at the same time – they may prevent the medicine from working.
- Follow the package leaflet and your doctor's advice. This page is for information only and is not an offer to buy the medicine online.
What is Trasolette used for and how should it be taken?
Basic information about the medicine
| Name of the medicine | Trasolette®, 1 mg, film-coated tablets |
|---|---|
| Active substance | anastrozole |
| Strength | 1 mg anastrozole per film-coated tablet |
| Pharmaceutical form | film-coated tablet |
| Therapeutic group | endocrine therapy – aromatase inhibitors (ATC L02BG03) |
| Pack | 28 film-coated tablets (2 blisters of 14) |
| Marketing authorisation holder and manufacturer | PharmaSwiss d.o.o., Belgrade |
| Supply status | R – prescription only |
What is Trasolette used for?
According to the summary of product characteristics, Trasolette is indicated in postmenopausal women for:
- treatment of hormone receptor-positive advanced breast cancer;
- adjuvant (additional) treatment of hormone receptor-positive early invasive breast cancer;
- adjuvant treatment of hormone receptor-positive early invasive breast cancer in women who have previously received 2 to 3 years of tamoxifen.
How is Trasolette used and dosed?
| Adult postmenopausal women, including the elderly | 1 tablet (1 mg) once a day |
|---|---|
| Duration in early breast cancer | the recommended duration of adjuvant hormonal therapy is 5 years; the doctor decides on the duration |
| How to take | swallow the tablet whole with a little water, always at the same time; it does not matter whether before, with or after a meal |
Do not stop treatment until your doctor tells you to – treatment is long-term and may last several years.
Special patient groups
- Children and adolescents: the medicine is not used.
- Kidney impairment: no dose change in mild and moderate impairment; in severe impairment the medicine is used with caution.
- Liver impairment: no dose change in mild impairment; special caution is needed in moderate and severe impairment.
- Premenopausal women: the medicine is not used; if in doubt, menopause is confirmed by hormone tests.
Contraindications – when the medicine must not be used
- allergy (hypersensitivity) to anastrozole or any of the excipients;
- pregnancy and breastfeeding.
Precautions and warnings
- Tell your doctor if you still have menstrual periods, take tamoxifen or oestrogen-containing medicines, have had osteoporosis or have liver or kidney disease.
- Bones: because oestrogen is lowered, bones may become weaker and more prone to fractures; in women with or at risk of osteoporosis, bone density is measured at the start and periodically, and the doctor may start bone-protecting treatment.
- If you go into hospital, tell the staff that you are taking Trasolette.
- The medicine contains lactose; it contains less than 1 mmol sodium per tablet.
Interactions with other medicines, food and drink
- Tamoxifen and other selective oestrogen receptor modulators – do not take at the same time (they reduce the effect of anastrozole).
- Oestrogen-containing medicines, including hormone replacement therapy – do not take at the same time.
- LHRH analogues (gonadorelin, buserelin, goserelin, leuprorelin, triptorelin) – tell your doctor; there are no data supporting their combination with anastrozole.
- Tell your doctor about all medicines, including herbal products and non-prescription medicines.
Pregnancy and breastfeeding
- The medicine must not be taken during pregnancy and breastfeeding. If you become pregnant, stop taking the medicine and contact your doctor.
Driving and using machines
- The medicine is unlikely to affect the ability to drive or use machines, but some people occasionally feel weak or sleepy – in that case ask your doctor for advice.
Possible side effects
- Very common (more than 1 in 10): headache, hot flushes, nausea, rash, joint pain or stiffness, joint inflammation, weakness, loss of bone mass (osteoporosis), depression.
- Common (up to 1 in 10): loss of appetite, raised cholesterol, sleepiness, carpal tunnel syndrome, tingling or burning of the skin, loss of taste, diarrhoea, vomiting, changes in liver tests, thinning hair, allergic reactions of the face, lips or tongue, bone and muscle pain, vaginal dryness, vaginal bleeding (usually in the first weeks).
- Uncommon (up to 1 in 100): inflammation of the liver, hives, trigger finger, raised calcium in the blood.
- Rare (up to 1 in 1,000): skin inflammation with red patches or blisters, hypersensitivity rash, inflammation of small blood vessels (Henoch-Schönlein purpura).
- Very rare: Stevens-Johnson syndrome and angioedema – require stopping the medicine and urgent help.
Overdose, missed dose and stopping treatment
- Overdose: if you have taken more tablets than you should, contact your doctor or pharmacist immediately.
- Missed dose: take the next dose at the usual time; do not take a double dose.
- Stopping treatment: do not stop taking your tablets unless your doctor advises you to.
When to seek medical help immediately?
- a severe skin reaction with blisters, sores or peeling skin (Stevens-Johnson syndrome) – stop taking the medicine;
- swelling of the face, lips, tongue or throat with difficulty swallowing or breathing (angioedema) – stop taking the medicine;
- yellowing of the skin or eyes, marked weakness (possible liver inflammation);
- nausea, vomiting and increased thirst (possible raised blood calcium);
- vaginal bleeding that continues after the first weeks of treatment.
Pharmacist's advice
Take the tablet every day at the same time – linking it to a routine (e.g. breakfast) helps you not to miss a dose over years of treatment. If you forget a dose, simply continue the next day; do not take two tablets at once.
Ask your doctor about bone density testing and about calcium and vitamin D intake, and exercise regularly within your abilities. Joint pain and stiffness are common – tell your doctor if they bother you rather than stopping treatment yourself. Do not take products with oestrogen or phyto-oestrogens without your oncologist's advice.
Availability and price
Trasolette is a prescription medicine used in treatment managed by an oncologist. This page is for information only – the medicine cannot be ordered online. For availability, price and supply conditions, please contact a pharmacy.
Related information
During treatment, regular oncology check-ups and monitoring of bone density and blood lipids as agreed with your doctor are important.
Composition, pack and manufacturer
- Active substance: anastrozole – 1 mg per film-coated tablet.
- Excipients – core: lactose monohydrate; povidone K 25; sodium starch glycolate (type A); magnesium stearate; coating: hypromellose, macrogol 6000, titanium dioxide (E171), modified starch, cottonseed oil.
- Appearance and pack: white, round biconvex film-coated tablets; PVC/Alu blister of 14 tablets, 2 blisters per carton (28 tablets).
- Marketing authorisation holder and manufacturer: PharmaSwiss d.o.o., Batajnički drum 5A, Belgrade. Authorisation 000457632 2023 dated 21.05.2024.
Storage
- Store below 30 °C.
- Shelf life: 5 years; do not use after the expiry date stated on the pack.
- Keep out of the sight and reach of children. Return unused medicine to a pharmacy that collects unused medicines.
Frequently asked questions
How long is Trasolette taken?
Treatment is long-term. In early invasive breast cancer the recommended duration of adjuvant hormonal therapy is 5 years, and the doctor decides on the exact duration.
Does Trasolette affect the bones?
Yes. The medicine lowers oestrogen, which can reduce bone mineral density and increase the risk of fractures. The doctor assesses the risk, measures bone density if needed and may start bone-protecting treatment.
Can I use hormone therapy for menopausal symptoms with Trasolette?
No. Oestrogen-containing medicines, including hormone replacement therapy, are not taken with anastrozole because they cancel its effect. Discuss relief of symptoms with your doctor.
Is it normal for my joints to hurt?
Joint pain, stiffness and inflammation are among the very common side effects. Tell your doctor if the symptoms become marked – do not stop treatment on your own.
Sources
- ALIMS – Patient information leaflet Trasolette 1 mg (PIL)
- ALIMS – Summary of product characteristics Trasolette 1 mg (SmPC)
Sources checked on: 25 October 2026.
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