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Tantum Verde 1.5 mg/mL oromucosal spray 30 mL – sore throat and mouth inflammation
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- Stock: Zabrana online prodaje
- Brand: Angelini Pharma products
- Model: BR-5121352
Tantum Verde oromucosal spray is a benzydamine hydrochloride solution with a strength of 1.5 mg/mL (0.15%) in a 30 mL spray bottle. Benzydamine belongs to the group of stomatological preparations for local treatment of the oral mucosa (ATC A01AD02).
Benzydamine has anti-inflammatory and analgesic effects, a moderate local anaesthetic effect and disinfectant properties. The spray is intended especially for people who find gargling difficult; one spray delivers 0.17 mL of solution containing 255 micrograms of benzydamine hydrochloride.
Important warning
- Supply status in Serbia: medicine available without a prescription (according to the leaflet approved by ALIMS).
- The medicine is for short-term use; if there is no improvement after 3 days or the condition worsens, consult a doctor.
- Caution if you are allergic to acetylsalicylic acid or other anti-inflammatory medicines and in bronchial asthma.
- Contains parabens and mint flavour with allergens (e.g. D-limonene, linalool, eugenol).
- This page is for information only and is not an offer to buy the medicine online.
What is Tantum Verde spray used for and how many sprays are allowed?
Key facts about the medicine
| Medicine name | Tantum Verde®, 1.5 mg/mL, oromucosal spray, solution |
|---|---|
| Active substance | benzydamine (as benzydamine hydrochloride) |
| Strength | 1.5 mg/mL (0.15%); 255 micrograms benzydamine hydrochloride per spray |
| Pharmaceutical form | oromucosal spray, solution (oropharyngeal use) |
| Therapeutic group | stomatological preparations; other agents for local oral treatment (ATC A01AD02) |
| Pack | polyethylene bottle with spray pump, 1 × 30 mL |
| Marketing authorisation holder | Bonifar d.o.o., Novi Beograd |
| Manufacturer | Aziende Chimiche Riunite Angelini Francesco ACRAF S.p.A., Ancona, Italy |
| Supply status | available without a prescription |
What is Tantum Verde spray used for?
According to the patient leaflet, the spray is used for symptomatic treatment of:
- irritation and inflammation of the mouth and throat, e.g. gingivitis (gum inflammation), stomatitis (inflammation of the oral mucosa) and pharyngitis (inflammation of the pharynx)
- complaints after conservative or extractive dental procedures (e.g. caries removal or tooth extraction)
The spray is intended for patients who have difficulty gargling.
How is it used and dosed?
The medicine is sprayed directly onto the affected area in the mouth or throat. The recommended dose must not be exceeded.
- Adolescents over 12 years and adults: 4–8 sprays, 2 to 6 times a day.
- Children aged 6 to 12 years: 4 sprays, 2 to 6 times a day.
- Children aged 3 to 6 years: 1 spray per 4 kg of body weight, 2 to 6 times a day, no more than 4 sprays per application.
- Before first use, press the pump several times until an even spray appears; hold the bottle upright, raise the nozzle to a 90° angle and direct it at the application site.
- Do not eat or drink immediately after use, as this may reduce the effectiveness of the medicine.
- Use for a short time only; if there is no improvement after 3 days or the condition worsens, consult a doctor.
Special patient groups
- Children: dosing is based on age, and for children aged 3 to 6 years on body weight; the leaflet does not give a dose for children under 3 years.
- Elderly and people with kidney or liver impairment: the leaflet does not specify a dose adjustment.
Contraindications – when the medicine must not be used
The medicine must not be used in case of hypersensitivity (allergy) to benzydamine or any of the excipients.
Precautions and warnings
- In a small number of patients, more serious damage of the mouth and throat mucosa (bucco-pharyngeal ulceration) may occur as a result of a serious disease – a doctor is then needed.
- Tell your doctor if you are allergic to acetylsalicylic acid or other anti-inflammatory medicines, or if you have had bronchial asthma.
- Prolonged use of benzydamine may lead to sensitisation; in that case stop using it and consult a doctor.
- The medicine contains methyl and propyl parahydroxybenzoate (may cause immediate or delayed allergic reactions) and mint flavour with anisyl alcohol, benzyl alcohol, D-limonene, linalool and eugenol, which may cause allergic reactions.
Interactions with other medicines, alcohol and food
The leaflet does not list specific interactions with other medicines; nevertheless, tell your doctor or pharmacist about all medicines you take. Do not eat or drink immediately after use.
Pregnancy and breastfeeding
Tantum Verde spray should not be used during pregnancy and breastfeeding unless a doctor has assessed the benefit and risk.
Driving and using machines
When used correctly and according to the leaflet, there is no evidence that the medicine affects the ability to drive or use machines.
Possible side effects
- Uncommon (up to 1 in 100 patients): sensitivity to light (photosensitivity).
- Rare (up to 1 in 1,000): burning in the mouth, dry mouth, numbness at the application site right after use (part of the medicine's action, passes quickly), nausea, vomiting.
- Very rare (up to 1 in 10,000): laryngospasm (swelling of the larynx), angioedema (swelling of the face and tongue).
- Frequency not known: allergic reactions, including anaphylactic shock.
If any of the above side effects occurs, stop using the medicine and contact a doctor immediately.
Suspected side effects can be reported to your doctor, pharmacist or the Medicines and Medical Devices Agency of Serbia (ALIMS).
Overdose, missed dose and stopping treatment
- Overdose: if you use too much or accidentally swallow a large amount, contact a doctor or pharmacist immediately. According to the SmPC, poisoning is expected only after accidental ingestion of large amounts of benzydamine (more than 300 mg), most often in children, with symptoms such as nausea, vomiting, agitation, tremor and convulsions.
- Missed dose: do not take a double dose to make up for a missed one.
- Stopping treatment: you can stop using it whenever you wish without health consequences.
When to seek medical help immediately?
- difficulty breathing, a feeling of tightness in the throat or sudden hoarseness (possible swelling of the larynx)
- swelling of the face, lips, tongue or throat, severe itching or blistering of the skin, dizziness or fainting
- high fever, difficulty swallowing or opening the mouth, one-sided swelling in the throat
- sores in the mouth or throat that spread or do not heal, or no improvement after 3 days
Pharmacist's advice
The spray is practical when gargling is difficult – e.g. in children from 3 years or people with a very sore throat. Spray it directly onto the painful area and do not eat or drink immediately afterwards, so the medicine is not washed away from where it acts.
Brief numbness or mild burning after use are expected. In children aged 3 to 6 years the number of sprays depends on body weight (1 spray per 4 kg, maximum 4) – check the child's weight before use.
Availability and price
The medicine is available without a prescription, but under the regulations of the Republic of Serbia it cannot be ordered online. This page is for information only.
Please contact a pharmacy to check availability.
Related information
For additional care and support with sore and inflamed throat, see also the Throat problems category – products in this category do not replace the medicine you have been prescribed.
Composition, packaging and manufacturer
- 100 mL of solution contains 0.15 g benzydamine hydrochloride, equivalent to 0.134 g benzydamine; one spray (0.17 mL) contains 255 micrograms benzydamine hydrochloride.
- Excipients: glycerol; sorbitol, liquid, crystallising; saccharin sodium; acesulfame potassium; methyl parahydroxybenzoate; propyl parahydroxybenzoate; mint flavour (anisyl alcohol, benzyl alcohol, D-limonene, linalool, eugenol); polysorbate 20; purified water.
- Appearance: clear, colourless solution.
- Pack: 30 mL polyethylene bottle with spray pump, in a carton with the leaflet.
- Marketing authorisation holder: Bonifar d.o.o., Bulevar Zorana Đinđića 64a, Novi Beograd. Manufacturer: Aziende Chimiche Riunite Angelini Francesco ACRAF S.p.A., Ancona, Italy.
Storage
- The medicine does not require any special storage conditions.
- Shelf life is 4 years.
- Keep out of the sight and reach of children; do not use after the expiry date on the pack.
- Return unused medicine to a pharmacy that collects unused medicines.
Frequently asked questions
How many times a day can Tantum Verde spray be used?
2 to 6 times a day. Adults and children over 12 use 4–8 sprays, children aged 6 to 12 use 4 sprays, and children aged 3 to 6 use 1 spray per 4 kg of body weight (maximum 4).
Is it normal for the tongue or throat to feel numb after the spray?
Yes. Brief numbness and mild burning are described in the leaflet as part of the medicine's action and pass quickly.
What is the difference between Tantum Verde spray and Tantum Verde Forte spray?
Tantum Verde spray contains 1.5 mg/mL benzydamine, while Tantum Verde Forte contains 3 mg/mL and comes in a 15 mL bottle. They are different strengths with different dosing – follow the leaflet of the exact medicine you are using.
Can I use Tantum Verde spray after a tooth extraction?
Yes, the leaflet lists use for complaints after dental procedures, including tooth extraction. If severe pain, swelling or bleeding that does not stop occurs, contact your dentist.
Sources
- ALIMS – Patient leaflet Tantum Verde, 1.5 mg/mL, oromucosal spray, solution (May 2022)
- ALIMS – Summary of Product Characteristics Tantum Verde oromucosal spray (authorisation 515-01-02538-21-001 of 23.05.2022)
Date sources were checked: 23 October 2026.
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Additional information
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Shipping cost
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