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Propafen 150 mg and 300 mg film-coated tablets (propafenone) – treatment and prevention of arrhythmias
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- Stock: Zabrana online prodaje
- Brand: HEMOFARM-EN
- Model: BR-16445210
Propafen is an antiarrhythmic medicine (class IC) containing propafenone hydrochloride. It slows the heart rate and helps regulate the heart rhythm, so it is used to treat and prevent irregular heart rhythm (arrhythmias).
The medicine is available as film-coated tablets of 150 mg and 300 mg propafenone hydrochloride. Both strengths have a score line and can be divided into equal doses.
Important warning
- Dispensing status: the medicine is available only on prescription.
- It is advisable to start treatment in hospital, under the supervision of a doctor experienced in treating arrhythmias, with ECG monitoring and blood pressure measurement.
- Grapefruit and grapefruit juice must not be consumed during treatment, as they increase the level of the medicine in the blood.
- Do not stop treatment on your own – your condition may get worse.
- This page is for information only and is not an offer to buy the medicine online.
What is Propafen used for and how should it be taken correctly?
Basic information about the medicine
| Medicine name | Propafen, 150 mg and 300 mg, film-coated tablets |
|---|---|
| Active substance | propafenone (propafenone hydrochloride) |
| Strength | 150 mg or 300 mg propafenone hydrochloride per film-coated tablet |
| Pharmaceutical form | film-coated tablet (with score line) |
| Therapeutic group | antiarrhythmics, class IC (ATC C01BC03) |
| Pack | 50 film-coated tablets (5 blisters of 10) for each strength |
| Marketing authorisation holder / manufacturer | Hemofarm a.d. Vršac (marketing authorisation holder and manufacturer) |
| Dispensing status | R – prescription only |
What is Propafen used for?
According to the summary of product characteristics, Propafen is intended:
- for the prevention and treatment of ventricular arrhythmias (rhythm disorders originating in the heart chambers);
- for the prevention and treatment of paroxysmal supraventricular tachyarrhythmias, including paroxysmal atrial flutter/fibrillation and paroxysmal re-entrant tachycardia (involving the AV node or accessory pathways), when standard therapy is ineffective or contraindicated.
How is Propafen used and dosed?
The dose is determined by the doctor with ECG and blood pressure monitoring. According to the leaflet and the summary of product characteristics:
- Adults – starting dose: 150 mg three times daily.
- Dose increase: at intervals of at least three days (the dose may only be increased after 3 to 4 days of treatment) to 300 mg twice daily and, if necessary, up to a maximum of 300 mg three times daily.
- A lower total daily dose is recommended for people weighing less than 70 kg.
- Swallow the tablet whole without chewing (bitter taste and local anaesthetic effect), after a meal, with sufficient liquid.
Special patient groups
- Children: use is not advised – a suitable dose for children is not available.
- Older people: the doctor may reduce the dose; starting treatment and increasing the dose should be gradual, and the dose should not be increased before 5 to 8 days of treatment.
- Liver and/or kidney impairment: the medicine may accumulate; the dose is adjusted with ECG monitoring and measurement of drug levels in the blood.
- Pacemaker: adjustment of the settings may be required.
Contraindications – when the medicine must not be used
- allergy to propafenone hydrochloride or the excipients;
- Brugada syndrome;
- myocardial infarction in the last 3 months;
- severe heart failure or another significant heart disease not related to the rhythm disorder;
- cardiogenic shock (unless caused by an arrhythmia);
- very slow heartbeat, markedly low blood pressure;
- electrolyte disturbances in the blood (e.g. sodium or potassium);
- severe obstructive lung disease (chronic bronchitis, emphysema);
- myasthenia gravis;
- concomitant use of ritonavir;
- without an implanted pacemaker: sinus node dysfunction, atrial conduction defects, second- or higher-degree AV block, bundle branch block or distal block.
Precautions and warnings
- risk of developing heart failure;
- obstructive lung disease or asthma;
- pregnancy, planning a pregnancy or breastfeeding;
- planned surgery or dental treatment – tell the surgeon or dentist that you take propafenone, as it may affect the action of anaesthetics;
- implanted pacemaker – adjustment may be needed;
- before and during treatment your doctor may perform an ECG and measure your blood pressure to determine the dose.
Interactions with other medicines, food and drink
Tell your doctor or pharmacist about all medicines you take, including non-prescription medicines, especially:
- amiodarone, digoxin, quinidine;
- anticoagulants such as warfarin;
- erythromycin, rifampicin, ketoconazole;
- beta blockers (metoprolol, propranolol);
- ritonavir;
- anxiolytics, tricyclic and related antidepressants (desipramine, amitriptyline, dosulepin), venlafaxine, fluoxetine, paroxetine;
- cimetidine, ciclosporin, theophylline, phenobarbital.
Grapefruit and grapefruit juice must not be consumed during treatment. The medicine is taken after a meal with sufficient liquid.
Pregnancy and breastfeeding
- Pregnancy: use is not recommended unless necessary because the pregnant woman’s health is at risk and the benefit for the mother outweighs the risk to the baby.
- Breastfeeding: the medicine should be used with caution in breastfeeding women.
Driving and using machines
- Driving, operating machinery and activities requiring increased attention are not recommended during treatment. The medicine may cause blurred vision, dizziness, tiredness and a fall in blood pressure on standing up.
Possible side effects
- Contact your doctor immediately: seizures (convulsions); life-threatening rhythm disorder; difficulty breathing and swelling around the ankles; rash, itching, redness or difficulty breathing (allergy); yellowing of the skin or eyes; bruising or sore throat with high fever (low platelet or white blood cell count).
- Very common: dizziness, irregular (slow) heartbeat, palpitations and skipped beats.
- Common: restlessness, sleep disturbances, headache, taste disturbance, blurred vision, slow or fast heartbeat, difficulty breathing, abdominal pain, vomiting, nausea, diarrhoea, constipation, dry mouth, increased liver enzymes, chest pain, tiredness, exhaustion, raised body temperature.
- Uncommon: low platelet count, reduced appetite, nightmares, sudden loss of consciousness, gait and coordination disturbances, tingling in the limbs, vertigo, serious arrhythmia (ventricular tachycardia), fall in blood pressure, bloating, hives, itching, rash, reduced potency.
- Frequency not known: low white blood cell count (including agranulocytosis), confusion, convulsions, extrapyramidal symptoms, ventricular fibrillation, heart failure, fall in blood pressure on standing, liver damage and jaundice, acute generalised exanthematous pustulosis, lupus-like syndrome, reduced sperm count (temporary).
Overdose, missed dose and stopping treatment
- Overdose: contact a doctor, pharmacist or the nearest healthcare facility immediately and take the leaflet with you.
- Missed dose: take it as soon as possible; if it is nearly time for the next dose, skip the missed one and continue as scheduled. Never take a double dose.
- Stopping treatment: do not stop the medicine without your doctor’s advice, even if you feel better – your condition may get worse.
When to seek medical help immediately?
- seizures or loss of consciousness;
- very fast, irregular or markedly slow heartbeat, fainting;
- difficulty breathing and swelling around the ankles (signs of heart failure);
- yellowing of the skin or eyes;
- high fever with sore throat or unexplained bruising.
Pharmacist's advice
Take Propafen after meals, at regular intervals during the day, and swallow the tablet whole – because of its bitter taste and slight numbing of the mouth, it should not be chewed. Avoid grapefruit and grapefruit juice completely, and talk to your pharmacist first about any new medicine, including non-prescription ones.
Regular ECG check-ups are part of the treatment, because your doctor adjusts the dose based on them. If you feel stronger palpitations, faintness or dizziness, do not wait for the next check-up.
Availability and price
Propafen is a prescription medicine dispensed in pharmacies. ApotekaOnline.rs does not sell medicines over the internet; this page is for information only – check availability at a pharmacy.
Related information
For measuring blood pressure and pulse at home, which your doctor may ask for during dose adjustment, see also the category Blood pressure monitors – products in this category do not replace the medicine prescribed to you or ECG monitoring.
Composition, pack and manufacturer
- active substance: propafenone hydrochloride – 150 mg or 300 mg per film-coated tablet;
- excipients – core: microcrystalline cellulose; maize starch; colloidal anhydrous silica; magnesium stearate; copovidone; film: hypromellose; talc; titanium dioxide; propylene glycol; dimeticone;
- 150 mg: round, white to almost white film-coated tablets with a score line; 300 mg: round, bevelled, white to almost white film-coated tablets with a score line – both can be divided into equal doses;
- pack: 5 blisters of 10 film-coated tablets (50 tablets);
- marketing authorisation holder and manufacturer: Hemofarm a.d. Vršac, Beogradski put bb, Vršac, Serbia.
Storage
- store below 25 °C;
- shelf life: 3 years;
- keep out of the sight and reach of children; return unused medicine to a pharmacy that collects unused medicines.
Frequently asked questions
Why is Propafen treatment often started in hospital?
According to the summary of product characteristics, it is advisable to start treatment in hospital, under the supervision of a doctor experienced in treating arrhythmias, because the dose is determined with ECG monitoring and blood pressure control.
Can I eat grapefruit while taking Propafen?
No. Grapefruit and grapefruit juice must not be consumed during treatment, as they increase the level of propafenone in the blood.
How is the dose increased?
The starting dose is 150 mg three times daily. The doctor may increase it at intervals of at least three days to 300 mg twice daily and, if necessary, up to a maximum of 300 mg three times daily; in older people the dose is not increased before 5 to 8 days of treatment.
Why should the tablet not be chewed?
Propafenone has a bitter taste and a local anaesthetic effect, so the tablet is swallowed whole, without chewing, with sufficient liquid after a meal.
Sources
- ALIMS – Patient information leaflet Propafen 150 mg (PIL)
- ALIMS – Summary of product characteristics Propafen 150 mg (SmPC)
- ALIMS – Patient information leaflet Propafen 300 mg (PIL)
Sources checked on: 25 October 2026.
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