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PIPTAZ
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- Stock: Zabrana online prodaje
- Brand: PHARMA SWISS
- Model: BR-16710
Piptaz® is a combination of two antibiotics in the form of a powder for solution for infusion. Piperacillin belongs to the broad-spectrum penicillin antibiotics and kills many types of bacteria, while tazobactam can prevent the survival of some bacteria resistant to piperacillin, so together they kill more bacteria.
Each vial contains 4 g piperacillin and 0.5 g tazobactam, with no excipients. The medicine is given by intravenous infusion in hospital only. The marketing authorisation holder and manufacturer is PharmaSwiss d.o.o. Belgrade.
Important warning
- Supply status: for use only in an inpatient healthcare facility.
- It must not be given in case of allergy to penicillins, cephalosporins or beta-lactamase inhibitors.
- A skin rash or blisters during treatment may be a sign of a serious reaction – tell your doctor immediately.
- If diarrhoea occurs during or after treatment, tell your doctor and do not take anti-diarrhoeal medicines without advice.
- Each vial contains 256 mg sodium.
What Piptaz is used for and how it is given
Key facts about the medicine
| Name of the medicine | Piptaz®, 4 g + 0.5 g, powder for solution for infusion |
|---|---|
| Active substances | piperacillin 4 g (as piperacillin sodium) and tazobactam 0.5 g (as tazobactam sodium) |
| Pharmaceutical form | powder for solution for infusion |
| Therapeutic group | broad-spectrum penicillins combined with a beta-lactamase inhibitor |
| Pack | 12 glass vials of 50 mL |
| Marketing authorisation holder and manufacturer | PharmaSwiss d.o.o., Belgrade |
| Supply status | inpatient healthcare facility only |
Indications
- adults and adolescents – bacterial infections of the lower respiratory tract (lungs), urinary tract (kidneys and bladder), abdomen, skin or blood;
- children aged 2 to 12 years – abdominal infections such as appendicitis, peritonitis and gallbladder infection;
- patients with a low white blood cell count – bacterial infections.
In some severe infections the doctor may combine Piptaz with other antibiotics.
Dosage and method of administration
A healthcare professional gives the medicine by intravenous infusion over 30 minutes. The dose depends on the infection, age and kidney function.
- Adults and adolescents over 12 years: 4 g + 0.5 g every 6 to 8 hours.
- Children aged 2–12 years, abdominal infections: 100 mg + 12.5 mg per kg every 8 hours.
- Children with a low white blood cell count: 80 mg + 10 mg per kg every 6 hours; a single dose does not exceed 4 g + 0.5 g.
- Impaired kidney function: the doctor may reduce the dose or extend the interval.
Treatment continues until the signs of infection have completely resolved, usually 5 to 14 days. It is not recommended for children under 2 years.
Contraindications – when the medicine must not be used
- allergy to piperacillin, tazobactam or other ingredients;
- allergy to antibiotics, including penicillins, cephalosporins or beta-lactamase inhibitors.
Warnings and precautions
- a history of multiple allergies;
- rash or blisters during treatment – possible sign of a serious reaction;
- previous diarrhoea or diarrhoea during/after treatment;
- low blood potassium, kidney or liver disease, haemodialysis – the doctor may monitor blood tests;
- use of anticoagulants or unexpected bleeding;
- seizures during treatment;
- a new or worsening infection;
- the medicine may affect laboratory blood and urine tests.
Interactions with other medicines
- probenecid – prolongs the elimination of piperacillin and tazobactam;
- anticoagulants (heparin, warfarin, aspirin);
- muscle relaxants used during surgery – tell your doctor if you will have general anaesthesia;
- methotrexate – may be eliminated more slowly;
- medicines that lower potassium (e.g. diuretics);
- other antibiotics (tobramycin, gentamicin, vancomycin) – especially with kidney disease.
Pregnancy and breast-feeding
Piperacillin and tazobactam may cross the placenta and pass into breast milk. The doctor decides whether the medicine is suitable during pregnancy and breast-feeding.
Driving and using machines
No effect on the ability to drive or use machines is expected.
Possible side effects
Very common: diarrhoea. Common: fungal infections, reduced platelets, red blood cells or haemoglobin, abnormal laboratory results and prolonged clotting time, as well as other effects listed in the leaflet.
Serious but less frequent or of unknown frequency: severe skin rashes (Stevens-Johnson syndrome, toxic epidermal necrolysis), drug reaction with eosinophilia and systemic symptoms that can affect the kidneys and liver, acute generalised exanthematous pustulosis.
When to seek medical help immediately
- red spots or circular patches with blisters, mouth ulcers, red swollen eyes, peeling skin;
- rash with high fever, swelling, jaundice or signs of kidney and liver involvement;
- persistent or bloody diarrhoea;
- unexpected bleeding or seizures.
Pharmacist's advice
Before treatment, always tell the doctor about all allergies, especially to penicillins and cephalosporins, and if you take blood thinners or methotrexate. If you develop diarrhoea during or after treatment, do not take anti-diarrhoeal medicines on your own – contact your doctor.
After antibiotic treatment some patients use probiotic products on a pharmacist's advice; however, always report persistent diarrhoea to a doctor.
Availability and price
Piptaz is used only in inpatient healthcare facilities and is not dispensed in pharmacies. This page is for information only and is not an offer to sell the medicine online.
For questions about your treatment, ask your treating doctor.
Composition, pack and manufacturer
- Active substances: piperacillin sodium and tazobactam sodium; each vial contains 4 g piperacillin and 0.5 g tazobactam.
- Excipients: none; each vial contains 256 mg sodium.
- Appearance: white to almost white powder.
- Pack: 50 mL glass vial with rubber stopper and flip-off cap; 12 vials per box.
- Marketing authorisation holder and manufacturer: PharmaSwiss d.o.o., Batajnički drum 5A, Belgrade.
Storage
- Keep out of the sight and reach of children.
- Before opening, store below 25 °C.
- The reconstituted and diluted solution (20 mL 0.9% NaCl or water for injections) is stable for 24 hours at 2–8 °C.
- Do not use after the expiry date.
Frequently asked questions
Why does Piptaz contain two antibiotics?
Piperacillin kills many types of bacteria, and tazobactam prevents the survival of some bacteria resistant to piperacillin, so the combination kills more bacteria.
How long does Piptaz treatment last?
Until the signs of infection have completely resolved, usually 5 to 14 days.
Is Piptaz given to children?
Yes, to children aged 2 to 12 years with abdominal infections or a low white blood cell count; it is not recommended for children under 2.
What if I get diarrhoea during treatment?
Tell your doctor immediately and do not take anti-diarrhoeal medicines without their advice.
Sources
Pharmacy Online has a contract with the Daily Express courier service and it is delivered on the territory of the Republic of Serbia through this service. Exports of goods to foreign countries are done through DHL and PostExport.
For all orders received up to 12h from Monday to Friday, the approximate delivery time is 2-4 business days for the whole territory of the Republic of Serbia. In case the order is placed on weekends (Saturdays and Sundays), the delivery is done as well as for the orders received on Monday - so next business day.
Deliveries are not made on Saturdays and Sundays.
Additional information
The items will be packed so that they cannot be damaged by normal handling of the goods in transit. When picking up the product, the buyer is obliged to check for any damage and immediately advertise it to the courier who delivered the goods, or refuse to take over the shipment, which shows the external damage. Any subsequent product claims for shipping damage will not be considered.
When picking up the product, the customer is required to sign the delivery note taken by the Daily Express delivery worker. The delivery note is considered to be a receipt and delivery note.
The courier service delivers the goods to the address, ie. does not bring into the living space.
Delivery restrictions on goods
Delivery of items purchased on the site www.apotekaonline.rs is made exclusively through the Daily Express courier service in the territory of the Republic of Serbia. Delivery outside the territory of the Republic of Serbia, ie export of goods, is done exclusively through the service of DHL and PostExport Post of Serbia.
Shipping cost
For the territory of the Republic of Serbia:
For goods ordered up to 5.000,00 RSD, delivery charge is 350.00 RSD (VAT included). For goods over 5.000,00 RSD, shipping is free of charge.
For international delivery:
For the export of goods abroad through the PostExport service of Post of Serbia, the shipping price is for:
- Zone I (Slovenia, Croatia, Bosnia and Herzegovina, Montenegro, Northern Macedonia) - 1,280.00 RSD
- Zone II (Other European countries) - 1,790.00 RSD
- Zone III (Asia, Africa, America, Australia and other countries) - 2,650.00 RSD
Delivery time is 15 days or more (depending on the country of delivery)
For export of goods abroad through DHL service, the shipping price is 2,700.00 RSD. Delivery time is 1-5 business days (depending on the country of delivery)
Shipping cost is with tax. The price includes the delivery of the parcel to the buyer's address with the associated tax and customs at the seller's expense. A possible additional cost may be a customs charge against the buyer, depending on the country to which the package is being shipped.
For any additional questions, complaints or checking the current location of your shipment, please contact us at the following e-mail address: info@apotekaonline.rs
