Nimulid 100 mg tablets – nimesulide for acute pain and painful periods (primary dysmenorrhoea)

Nimulid 100 mg tablets contain nimesulide, a medicine from the group of non-steroidal anti-inflammatory and antirheumatic drugs (NSAIDs, ATC M01AX17). It is used for short-term treatment of acute pain and primary dysmenorrhoea – painful periods that are not caused by disease but by natural processes in the body.

Nimesulide is prescribed only as second-line treatment, after the doctor has assessed the overall risk for each patient, because it can damage the liver. The medicine is taken for as short a time as possible and for no more than 15 days per treatment course.

What is Nimulid used for and how should it be taken?

Key facts about the medicine

What is Nimulid used for?

According to the approved leaflet and summary of product characteristics, Nimulid is used for:

• treatment of acute pain;
• treatment of primary dysmenorrhoea (painful periods).

Nimesulide should be prescribed only as second-line treatment; the decision is based on an assessment of the overall risk for each individual patient.

How is Nimulid taken and dosed?

Take the medicine exactly as your doctor has told you. According to the leaflet:

• Adults: 1 tablet (100 mg) twice daily, after meals.
• Adolescents aged 12 to 18 years: no dose adjustment is needed.
• Duration: as short as possible and no longer than 15 days per treatment course.
• Lowest effective dose: side effects are reduced by using the lowest dose that controls symptoms for the shortest possible time.

Special patient groups

• Children under 12 years: the medicine is not used (contraindicated).
• Older people: no need to reduce the daily dose, but the doctor periodically checks that the medicine is not causing stomach, kidney, heart or liver problems.
• Kidney impairment: in mild to moderate impairment (creatinine clearance 30–80 mL/min) the dose is unchanged; in severe impairment (below 30 mL/min) the medicine is contraindicated.
• Liver impairment: the medicine is contraindicated.

Contraindications – when the medicine must not be used

• allergy to nimesulide or the excipients; an allergic reaction (difficulty breathing, sneezing, runny or blocked nose, hives) after acetylsalicylic acid or other NSAIDs;
• previous liver damage caused by nimesulide; impaired liver function or raised liver enzymes;
• concomitant use of other medicines that affect the liver (e.g. paracetamol or other NSAIDs);
• heavy alcohol consumption; dependence on medicines or psychoactive substances;
• an active stomach or duodenal ulcer, recurrent ulcers or bleeding in the past; bleeding or perforation associated with NSAIDs;
• bleeding into the brain (stroke); other bleeding or blood clotting disorders;
• severe heart failure or severe kidney impairment;
• fever or flu-like symptoms;
• the last trimester of pregnancy and breast-feeding; children under 12 years.

Warnings and precautions

• Nimesulide may increase the risk of heart attack and stroke, especially at high doses and with longer use – tell your doctor if you have heart disease or risk factors (high blood pressure, diabetes, raised cholesterol, smoking).
• Symptoms of liver damage (loss of appetite, nausea, vomiting, abdominal pain, chronic tiredness, dark urine) – stop treatment immediately and contact your doctor.
• A history of ulcer, bleeding from the stomach or bowel, ulcerative colitis or Crohn’s disease; black stools or abdominal pain during treatment – stop the medicine immediately.
• Fever or flu-like symptoms during treatment – stop the medicine and tell your doctor.
• Weak heart or kidney function, high blood pressure or circulation problems – kidney function may worsen.
• Serious allergic reactions or skin changes (including round or oval red patches, blisters, hives) – stop the medicine and contact your doctor.
• Nimulid may reduce fertility in women; it is not recommended for women planning pregnancy.
• The medicine contains lactose.

Interactions with other medicines, food and drink

Tell your doctor or pharmacist about all medicines you take. According to the leaflet, caution is needed with:

• anticoagulants (e.g. warfarin) and antiplatelet medicines (e.g. acetylsalicylic acid);
• blood pressure medicines and diuretics;
• lithium; methotrexate; ciclosporin;
• selective serotonin reuptake inhibitors (antidepressants);
• corticosteroids.

Concomitant use of other NSAIDs, including acetylsalicylic acid at anti-inflammatory doses (≥ 1 g single dose or ≥ 3 g per day), is not recommended, and paracetamol and other medicines affecting the liver are contraindicated. Do not drink alcohol during treatment.

Pregnancy and breast-feeding

• Pregnancy: the medicine must not be used in the last three months of pregnancy and is not recommended in the first and second trimester. From the sixth month of pregnancy it must not be used under any circumstances, as it can seriously harm the baby’s heart, lungs and kidneys. It is also not recommended for women trying to become pregnant.
• Breast-feeding: the medicine must not be used during breast-feeding.

Driving and using machines

• There are no data that Nimulid affects driving or using machines, but if dizziness, fainting or drowsiness occur, do not drive or use machines.

Possible side effects

Stop taking the medicine and contact your doctor immediately if you notice: discomfort or pain in the stomach, bleeding from the stomach or bowel or black stools; loss of appetite, weakness, nausea, vomiting or tiredness; rash or skin redness; wheezing or difficulty breathing; yellowing of the skin or whites of the eyes; unexpected changes in the amount or appearance of urine; swelling of the face, feet or legs.

Common (up to 1 in 10): diarrhoea, nausea, vomiting, raised liver enzymes.

Uncommon (up to 1 in 100): difficulty breathing, dizziness, raised blood pressure, constipation, bloating, gastrointestinal bleeding, stomach or duodenal ulcer and its perforation, itching, rash, increased sweating, swelling.

Rare and very rare: anaemia, eosinophilia, hypersensitivity, unstable blood pressure, difficulty passing or stopping urine, blood in the urine, raised potassium, anxiety, nightmares, blurred vision, fast heartbeat, anaphylaxis, severe skin reactions (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), kidney dysfunction, encephalopathy, Reye’s syndrome, hepatitis, sometimes very serious (fulminant, sometimes fatal), jaundice, asthma and bronchospasm, low platelet and white blood cell counts, worsening of colitis and Crohn’s disease. Frequency not known: heart failure, fixed drug eruption.

Overdose, missed dose and stopping treatment

• Overdose: talk to a doctor immediately or go to the nearest healthcare facility. The most common symptoms are lethargy, drowsiness, nausea, vomiting and upper abdominal pain; rarely raised blood pressure, acute kidney injury, respiratory depression and coma.
• Missed dose: do not take a double dose – take the next dose at the usual time.
• Stopping treatment: do not use the medicine for more than 15 days in one treatment course.

Related information

For additional care and support with painful periods, see also the category Menstrual pains – products in this category do not replace the medicine you have been prescribed.

Composition, pack and manufacturer

• Active substance: nimesulide – 100 mg per tablet.
• Excipients: lactose monohydrate; maize starch; croscarmellose sodium; colloidal anhydrous silica; povidone K30; docusate sodium; magnesium stearate; polysorbate 80.
• Appearance: round, slightly biconvex light yellow tablets embossed with “NIMULID” on one side and the manufacturer’s mark on the other.
• Pack: carton with 2 blue PVC/Alu blisters of 10 tablets (20 tablets).
• Marketing authorisation holder: Amicus SRB d.o.o., Milorada Jovanovića 9, Belgrade. Manufacturer: Yasenka d.o.o., Dvanaest redarstvenika 2/c, Vukovar, Croatia.
• Marketing authorisation number: 515-01-05090-22-001 of 20.11.2023 (renewal).

Storage

• Store below 30 °C in the original package to protect from light and moisture.
• Keep out of the sight and reach of children.
• Do not use after the expiry date; return unused medicine to a pharmacy that collects unused medicines.

Frequently asked questions

How long may I take Nimulid?

For as short a time as possible and no longer than 15 days per treatment course. Side effects are reduced by using the lowest dose that controls symptoms for the shortest possible time.

Can I take paracetamol or ibuprofen with Nimulid?

No. Concomitant use of paracetamol or other medicines affecting the liver is contraindicated, and combination with other NSAIDs (e.g. ibuprofen, acetylsalicylic acid at anti-inflammatory doses) is not recommended.

Is Nimulid suitable for painful periods?

Yes, primary dysmenorrhoea is an approved indication, but nimesulide is prescribed only as second-line treatment after a risk assessment. It is not recommended for women planning pregnancy, as it may reduce fertility.

Why is Nimulid not taken with fever and flu symptoms?

According to the leaflet, fever and flu-like symptoms are a contraindication. If they appear during treatment, the medicine should be stopped and the doctor informed.

Sources

• ALIMS – Package leaflet for Nimulid 100 mg tablets (PIL, Serbian)
• ALIMS – Summary of product characteristics for Nimulid 100 mg (SmPC, Serbian)

Date sources were checked: 25.10.2026.