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Methylergometrin HF 0.25 mg/ml oral drops (methylergometrine) – bleeding after childbirth and abortion
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- Stock: Zabrana online prodaje
- Brand: HEMOFARM-EN
- Model: BR-61206526
Methylergometrin HF oral drops contain methylergometrine maleate 0.25 mg/ml (1 ml = 20 drops). Methylergometrine is a semi-synthetic derivative of ergometrine, an ergot alkaloid. It increases the tone, rate and strength of rhythmic contractions of the uterine smooth muscle, which shortens the third stage of labour and reduces blood loss.
The medicine is used to prevent and treat bleeding after childbirth and abortion and to speed up shrinking of the uterus after childbirth. This page describes the oral drops (10 ml bottle); the same manufacturer also has a 0.2 mg/ml solution for injection, used in healthcare facilities, with a separate leaflet.
Important warning
- Supply status in Serbia: the oral drops are prescription-only.
- Must not be used in pregnancy, nor with high blood pressure, pre-eclampsia or eclampsia.
- Do not breastfeed during treatment and for at least 12 hours after the last dose; milk expressed during this time should be discarded.
- The most common side effect is a rise in blood pressure – severe headache, chest pain or convulsions require emergency help.
- This page is for information only and is not an offer to buy the medicine online.
When are Methylergometrin HF drops used after childbirth and how are they dosed correctly?
Key facts about the medicine
| Name of the medicine | Methylergometrin HF, 0.25 mg/ml, oral drops, solution |
|---|---|
| Active substance | methylergometrine (methylergometrine maleate) |
| Strength | 0.25 mg per 1 ml (20 drops); 1 drop ≈ 0.0125 mg |
| Pharmaceutical form | oral drops, solution (clear, colourless) |
| Therapeutic group | uterotonics, ergot alkaloids (ATC G02AB01) |
| Pack | 10 ml glass bottle with dropper |
| Marketing authorisation holder | Hemofarm AD Vršac (marketing authorisation holder and manufacturer) |
| Supply status (Serbia) | prescription-only medicine |
What is Methylergometrin HF used for?
According to the patient leaflet, Methylergometrin HF is used to:
- prevent and treat bleeding after childbirth and abortion;
- speed up shrinking of the uterus after childbirth (in uterine subinvolution – inadequate shrinking of the uterus).
The medicine is prescribed by a gynaecologist. Any heavy or prolonged bleeding after childbirth or abortion requires a medical examination.
How is it used and dosed?
| Parameter | According to the leaflet |
|---|---|
| Indication | puerperium (6 weeks after delivery) – uterine subinvolution and bleeding after childbirth |
| Dose | 0.125–0.187 mg (10–15 drops) three times daily |
| Duration | no longer than 7 days |
| Method of use | oral; food does not affect absorption – can be taken regardless of meals |
| Children and adolescents | efficacy and safety under 18 years not established |
- Count the drops carefully using the dropper in the pack.
- Do not exceed the prescribed dose or the 7-day duration.
- After first opening, use the bottle within 28 days at room temperature.
Special patient groups
- Breastfeeding mothers: breastfeeding is interrupted during treatment and for at least 12 hours after the last dose; expressed milk is discarded.
- Liver or kidney disease: tell the doctor before use.
- Sepsis: special precaution is needed.
- Children and adolescents: efficacy and safety not established.
Contraindications – when the medicine must not be used
Do not take Methylergometrin HF:
- if you are allergic to methylergometrine, ergometrine or any of the excipients;
- if you are pregnant;
- if you have hypertension (high blood pressure), including pre-eclampsia and eclampsia.
Precautions and warnings
Tell your doctor before use if you:
- have liver or kidney disease;
- have heart disease (mitral valve stenosis, heart failure);
- have coronary heart disease (angina) or risk factors – smoking, obesity, diabetes, high cholesterol;
- have had a heart attack, stroke or transient ischaemic attack;
- have Raynaud’s disease or another blood vessel disease.
The medicine contains methyl parahydroxybenzoate, which may cause allergic reactions (possibly delayed), and small amounts of ethanol (less than 100 mg per dose).
Interactions with other medicines, alcohol and food
The effect of the medicine may be increased by: macrolide antibiotics (erythromycin, troleandomycin, clarithromycin), quinupristin/dalfopristin, HIV medicines (ritonavir, indinavir, nelfinavir, saquinavir, delavirdine), antifungals (ketoconazole, itraconazole, voriconazole, fluconazole, clotrimazole), the antidepressants nefazodone, fluoxetine and fluvoxamine, cimetidine, zileuton, beta-blockers, other ergot alkaloids, triptans (migraine medicines), sympathomimetics (including in local anaesthetics), prostaglandins and grapefruit juice.
The effect may be reduced by: nevirapine, rifampicin, the anaesthetics halothane and methoxyflurane. Methylergometrine may weaken the effect of nitroglycerin and other angina medicines.
Grapefruit juice may cause a potentially dangerous interaction – talk to your doctor before taking it.
Pregnancy and breastfeeding
Pregnancy: the medicine must not be used in pregnancy because it increases uterine contractions.
Breastfeeding: during treatment mothers must not breastfeed and must wait at least 12 hours after the last dose before breastfeeding again; milk produced during this period should be discarded.
Driving and using machines
You may feel dizzy after taking the medicine. Do not drive or do tasks that require increased attention until you know how the medicine affects you.
Possible side effects
Contact a doctor immediately if any of the following occurs. The most common is a rise in blood pressure, in severe cases with convulsions and/or headache; a fall in blood pressure has also been reported. Abdominal pain (due to uterine contractions), nausea and vomiting occur occasionally.
Rare: acute myocardial infarction, transient chest pain, narrowing and spasm of blood vessels, coronary artery spasm, slow or fast heart rate, difficulty breathing, blood in the urine, superficial vein inflammation, water intoxication, hallucinations, leg cramps, fainting, ringing in the ears, stuffy nose, diarrhoea, sweating, palpitations, rash and an unpleasant taste. There are rare reports of anaphylactic reactions.
Post-marketing reports include stroke, pins and needles, ventricular fibrillation and tachycardia, angina and AV block. No misuse or dependence has been reported.
Overdose, missed dose and stopping treatment
- Overdose: contact a doctor immediately. Symptoms: nausea, vomiting, reduced urination, abdominal pain, numbness and tingling in the limbs, raised blood pressure, in severe cases low blood pressure (dizziness, fainting), difficulty breathing, low body temperature, convulsions and coma. Treatment is symptomatic with monitoring of breathing and heart function.
- Missed dose: take it as soon as possible; if it is nearly time for the next dose, continue as scheduled. Never take a double dose.
- Stopping: the doctor advises when to stop; treatment lasts no longer than 7 days.
When to seek medical help immediately?
- severe headache, blurred vision or convulsions (possible sudden rise in blood pressure)
- chest pain or tightness, irregular or very fast heartbeat
- cold, pale or numb fingers and toes, pain in the limbs
- heavy bleeding that does not stop, dizziness or fainting
- difficulty breathing, swelling of the face or throat
- weakness of one side of the body or speech disturbance
Pharmacist's advice
Count the drops precisely – 10 to 15 drops three times daily, for no longer than 7 days, as prescribed by the gynaecologist. Check your blood pressure from time to time during treatment and report severe headache, chest pain or cold, white fingers to the doctor immediately.
If you are breastfeeding, plan ahead: during treatment and for 12 hours after the last dose, express and discard the milk to maintain lactation. Do not drink grapefruit juice and tell the doctor about any antibiotics, antifungal or migraine medicines you take.
Availability and price
Methylergometrin HF drops are prescription-only. Under Serbian regulations medicines are not sold online – this page is for information only.
Please check availability and price in a pharmacy.
Composition, packaging and manufacturer
- Active substance: methylergometrine maleate – 1 ml solution (20 drops) contains 0.25 mg.
- Excipients: methyl parahydroxybenzoate, glycine, thiourea, ethanol 96%, glycerol, tartaric acid, purified water.
- Appearance: clear, colourless solution.
- Pack: 10 ml dark glass bottle with plastic dropper and cap, in a carton.
- Marketing authorisation holder and manufacturer: Hemofarm AD Vršac, Beogradski put bb. Authorisation: 000820357 2024 of 25 December 2024.
Storage
- Keep out of the sight and reach of children.
- Store below 25 °C.
- Shelf life after first opening: 28 days at room temperature.
- Do not use after the expiry date; return unused medicine to a pharmacy.
Frequently asked questions
How many drops of Methylergometrin are taken?
According to the leaflet, 10–15 drops (0.125–0.187 mg) three times daily, for no longer than 7 days. One ml of solution (20 drops) contains 0.25 mg methylergometrine maleate.
Can I breastfeed while taking Methylergometrin drops?
No. Do not breastfeed during treatment and for at least 12 hours after the last dose; milk produced during this time should be discarded.
Why must I not drink grapefruit juice with this medicine?
Grapefruit juice may increase the effect of methylergometrine and cause potentially dangerous effects; the leaflet advises talking to the doctor before taking grapefruit.
When must the medicine not be used?
In pregnancy, with high blood pressure (including pre-eclampsia and eclampsia) and with allergy to methylergometrine, ergometrine or the excipients.
Related information
For additional care and support with recovery after childbirth, see also the Maternity & Nursing – Essentials for Mom & Baby category – products in this category do not replace the medicine you have been prescribed.
Sources
- ALIMS – Patient Information Leaflet Methylergometrin HF 0.25 mg/ml oral drops (December 2024, in Serbian)
- ALIMS – Summary of Product Characteristics Methylergometrin HF 0.25 mg/ml oral drops (in Serbian)
Sources checked on: 23 October 2026.
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