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Megace 160 mg tablets and 40 mg/mL oral suspension – megestrol acetate
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- Stock: Zabrana online prodaje
- Brand: PHARMA SWISS
- Model: BR-688912061
Megace contains megestrol acetate, a progestogen (a medicine related to the natural hormone progesterone). Two forms with different uses are authorised in Serbia:
Megace 160 mg tablets – for treatment of certain hormone-dependent cancers, such as breast cancer; Megace 40 mg/mL oral suspension – for treatment of anorexia (loss of appetite) and weight loss due to cancer or AIDS. Dosing must never be transferred from one form to the other.
Important warning
- Dispensing status: both forms are available on prescription only; treatment is supervised by a specialist.
- Megestrol acetate increases the risk of blood clots (thrombophlebitis, pulmonary embolism) – caution with previous thrombosis; the suspension must not be taken with previous thromboembolic disorders.
- It may raise blood sugar – people with diabetes should check their glucose more often.
- It is not recommended in pregnancy; breastfeeding should be stopped during treatment.
- This page is for information only and is not an offer to buy the medicine online.
What is Megace used for and how is it taken correctly?
Basic information about the medicine
| Medicine name | Megace®, 160 mg, tablet; Megace®, 40 mg/mL, oral suspension |
|---|---|
| Active substance | megestrol acetate |
| Strength | 160 mg (tablet); 40 mg/mL (suspension) |
| Pharmaceutical form | tablet; oral suspension |
| Therapeutic group | endocrine therapy – progestogens (ATC L02AB01) |
| Pack | glass bottle with 30 tablets; plastic bottle with 240 mL suspension and 35 mL measuring cup |
| Marketing authorisation holder / manufacturer | PharmaSwiss d.o.o. Belgrade; manufacturers: Haupt Pharma Amareg GmbH, Regensburg, Germany (tablets); Bausch Health Poland, Poland (suspension) |
| Dispensing status | R – prescription only |
What is Megace used for?
According to the approved leaflets:
- 160 mg tablets – treatment of certain hormone-dependent neoplasms, such as breast cancer;
- 40 mg/mL oral suspension – treatment of anorexia and weight loss due to malignant neoplasm or AIDS, in patients of both sexes.
How is Megace used and dosed?
The dose and duration of treatment are determined by the doctor. Usual dosing according to the leaflets:
| Form | Usual dose | Notes |
|---|---|---|
| 160 mg tablets | 160 mg (1 tablet) daily | Take the tablet with enough water; the score line is only to aid swallowing, not to divide the dose. |
| 40 mg/mL oral suspension | 400–800 mg (10–20 mL) daily as a single dose | Shake the bottle before use; measure the dose with the cup provided. In people aged 65 and over the doctor may start with the lowest dose. |
- To assess efficacy, the medicine should be taken for at least 2 months without interruption; some patients take it for years.
- Keep taking the medicine until your doctor tells you otherwise.
Special patient groups
- Children: use is not recommended.
- Over 65 years: the doctor may monitor kidney function from time to time; with the suspension treatment may start with the lowest dose.
- Severe liver problems (tablets): talk to your doctor before starting treatment.
Contraindications – when the medicine must not be used
- allergy to megestrol acetate or any of the excipients (both forms);
- previous blood clotting problems – thromboembolic disorders (listed as a contraindication for the oral suspension).
Precautions and warnings
- thrombophlebitis (swollen veins with clots) now or in the past;
- diabetes – blood sugar may rise;
- severe liver problems (tablets);
- the tablets contain lactose and the suspension sucrose (may harm teeth), sodium benzoate and a small amount of ethanol – caution in sugar intolerance.
Interactions with other medicines, food and drink
- No interaction studies have been performed and there are no data on effects on other medicines. Nevertheless, tell your doctor about all medicines you take.
Pregnancy and breastfeeding
- Not recommended in pregnancy (for the tablets especially in the first 4 months); women of childbearing age should use contraception while taking the suspension.
- Because of possible side effects in the infant, breastfeeding should be stopped during treatment.
Driving and using machines
- The medicine has no or negligible influence on the ability to drive and use machines.
Possible side effects
- Very common (more than 1 in 10): increased appetite and weight gain (not related to fluid retention), shortness of breath, hot flushes and flushing of face and neck, high blood pressure, raised blood sugar, rounded face ("moon face"), constipation, swollen veins due to blood clots, blood clots in the lungs.
- Common (up to 1 in 10): temporary worsening of the underlying disease, mood changes, numbness or tingling in the fingers, heart attack or heart failure, hair loss, diarrhoea, tiredness, weakness, impotence, flatulence, frequent urination, nausea and vomiting, breakthrough or spotting vaginal bleeding, swelling (mainly of joints/ankles), pain, rash and hives.
Overdose, missed dose and stopping treatment
- Overdose: contact a doctor or emergency service immediately and take the medicine pack with you.
- Missed dose: take it as soon as you remember; if it is nearly time for the next dose, skip the missed one. Do not take a double dose.
- Stopping treatment: do not stop treatment without consulting your doctor.
When to seek medical help immediately?
- swelling of the face, lips or tongue, rash, difficulty breathing (allergic reaction) – stop the medicine;
- signs of a blood clot: pain, swelling or numbness of a leg (especially the calf), sudden shortness of breath, chest pain;
- loss of coordination, slurred speech, sudden weakness, severe headache or fainting;
- severe thirst, frequent urination and marked tiredness (possible high blood sugar).
Pharmacist's advice
Megace tablets and Megace suspension are not interchangeable – they have different uses and different doses. Check that you have the form prescribed to you, and measure the suspension only with the cup provided, after shaking the bottle.
During prolonged immobility (after surgery, on long journeys) move your legs often and drink enough fluids, and report calf pain or swelling to your doctor immediately. People with diabetes should measure their blood sugar more often.
Availability and price
Megace is a prescription-only medicine and treatment is managed by a specialist. ApotekaOnline.rs does not sell prescription medicines online, and this page is for information only.
Please check availability and price at a pharmacy with a valid prescription.
Related information
Megestrol acetate is used as part of specialist (oncology) treatment. For questions about nutrition and maintaining body weight during treatment, please contact your oncologist or the doctor managing your treatment.
Composition, pack and manufacturer
- Tablets: 160 mg megestrol acetate; excipients: lactose monohydrate; microcrystalline cellulose; sodium starch glycolate; povidone; colloidal anhydrous silica; magnesium stearate. Oval, almost white tablets with a score line and "160" marking; amber glass bottle with 30 tablets.
- Oral suspension: 40 mg megestrol acetate in 1 mL; excipients: anhydrous citric acid; polyethylene glycol 1450; polysorbate 80; sodium benzoate (E211); sodium citrate; sucrose; xanthan gum; lemon-lime flavour (with ethanol); purified water. White milky suspension; HDPE bottle with 240 mL and a 35 mL measuring cup.
- Marketing authorisation holder: PharmaSwiss d.o.o. Belgrade, Batajnički drum 5A; manufacturers: Haupt Pharma Amareg GmbH, Regensburg, Germany (tablets); Bausch Health Poland Sp. z o.o., Rzeszów/Mysłowice, Poland (suspension).
- Marketing authorisation numbers: tablets 000457570 2023 of 7 May 2024; oral suspension 002457753 2024 of 21 July 2025.
Storage
- Tablets: store below 30 °C.
- Oral suspension: store below 25 °C; shelf life after first opening 24 days.
- Keep out of the sight and reach of children.
Frequently asked questions
What is the difference between Megace tablets and Megace suspension?
The 160 mg tablets are used to treat hormone-dependent cancers (e.g. breast cancer), while the 40 mg/mL oral suspension is used to treat loss of appetite and weight in cancer or AIDS, at 400–800 mg daily. The forms are not interchangeable.
How soon can an effect be seen?
According to the leaflet, the medicine should be taken for at least 2 months without interruption to assess its efficacy.
Does Megace cause weight gain?
Yes – increased appetite and weight gain are very common and not related to fluid retention; with the suspension this is also the aim of treatment.
What should I watch out for during treatment?
Signs of a blood clot (leg pain and swelling, shortness of breath), raised blood sugar and allergic reactions – in these cases contact your doctor immediately.
Sources
- ALIMS – Patient information leaflet Megace 160 mg tablete (PIL)
- ALIMS – Summary of product characteristics Megace 160 mg tablete (SmPC)
- ALIMS – Patient information leaflet Megace 40 mg/mL oralna suspenzija (PIL)
- ALIMS – Summary of product characteristics Megace 40 mg/mL oralna suspenzija (SmPC)
Sources checked on: 25 October 2026.
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