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Naproksen HF 375 mg, 20 film-coated tablets – naproxen for joint and musculoskeletal inflammation
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- Stock: Zabrana online prodaje
- Brand: HEMOFARM-EN
- Model: BR-6056676415
Naproksen HF 375 mg is a non-steroidal anti-inflammatory drug – NSAID – containing naproxen. It reduces pain and inflammation and is prescribed for selected joint disorders, acute gout, acute musculoskeletal conditions and menstrual pain.
The pack contains 20 film-coated tablets with 375 mg of naproxen each. It is intended for adults and is available only on prescription in Serbia.
Naproxen may cause gastrointestinal ulceration, bleeding or perforation and may impair kidney, heart or liver function. The risk is greater in older patients, with higher doses, prolonged treatment and concurrent medicines that increase bleeding risk.
Do not combine Naproksen HF with ibuprofen, diclofenac, ketoprofen, another naproxen product, high-dose acetylsalicylic acid or another NSAID unless specifically instructed by a doctor.
Naproksen HF 375 mg – indications, dosage and precautions
Approved indications
- rheumatoid arthritis;
- osteoarthritis;
- ankylosing spondylitis;
- acute gout;
- acute musculoskeletal disorders, including strains, sprains and back pain;
- dysmenorrhoea – menstrual pain.
Naproxen reduces pain, swelling, stiffness and inflammation but does not cure the underlying rheumatic disease.
Administration and dosage
Take the medicine exactly according to the prescription. Swallow the tablet with water, with or immediately after food.
The score line allows the tablet to be divided into two equal doses.
| Indication | Dose range stated in the official leaflet | Important note |
|---|---|---|
| Rheumatoid arthritis, osteoarthritis and ankylosing spondylitis | A total of 500–1000 mg of naproxen daily, usually divided into two doses | The prescriber must specify the exact number of tablets |
| Acute gout | Initially 750 mg, followed by 250 mg every eight hours until the attack resolves | Do not calculate tablet quantities independently |
| Acute musculoskeletal disorders and dysmenorrhoea | Initially 500 mg, followed by 250 mg every 6–8 hours when required | Maximum after the first day: 1250 mg daily |
The official leaflet states total therapeutic naproxen doses, while each Naproksen HF tablet contains 375 mg. The prescriber must therefore specify the exact number of whole or divided tablets and the dosing schedule.
Older patients and people with reduced kidney function usually require a lower dose and shorter treatment.
Contraindications
- allergy to naproxen, naproxen sodium or an excipient;
- previous asthma, rhinitis, hives or angioedema caused by aspirin or another NSAID;
- active gastrointestinal ulcer or bleeding;
- recurrent ulceration or gastrointestinal bleeding;
- previous NSAID-related gastrointestinal bleeding or perforation;
- severe heart failure;
- severe kidney or liver impairment;
- the final three months of pregnancy.
Special precautions
Inform the doctor about hypertension, heart failure, heart attack, stroke, kidney or liver disease, previous ulceration, inflammatory bowel disease, asthma, bleeding disorders, lupus, severe skin reactions or planned surgery.
Gastrointestinal bleeding, ulceration and perforation may occur at any point during treatment, sometimes without warning symptoms.
NSAIDs may cause fluid retention, swelling, increased blood pressure and worsening heart or kidney function. Use the lowest effective dose for the shortest period required.
Important interactions
Important interacting medicines include:
- another NSAID or acetylsalicylic acid;
- warfarin, heparin, clopidogrel and other medicines affecting blood clotting;
- corticosteroids;
- SSRI antidepressants and lithium;
- diuretics and blood-pressure medicines;
- ciclosporin and tacrolimus;
- methotrexate;
- digoxin;
- phenytoin;
- quinolone antibiotics;
- sulfonylureas;
- probenecid;
- mifepristone;
- bisphosphonates;
- cholestyramine.
Take naproxen at least one hour before or four to six hours after cholestyramine. Alcohol is not recommended during treatment.
Pregnancy, breastfeeding and fertility
During the first and second trimesters, naproxen should be used only when considered necessary by a doctor, at the lowest dose for the shortest period.
It must not be used during the final three months of pregnancy.
Use while breastfeeding is not recommended. Naproxen may temporarily make conception more difficult.
Driving
Do not drive or operate machinery if dizziness, drowsiness, tiredness or visual disturbance occurs.
Possible side effects
- heartburn, indigestion, nausea, vomiting or abdominal pain;
- diarrhoea, constipation or wind;
- headache, dizziness or drowsiness;
- rash, itching or hives;
- fluid retention and swelling;
- increased blood pressure;
- tinnitus or visual disturbance;
- kidney or liver abnormalities;
- changes in blood-cell counts.
- vomiting blood or coffee-ground material;
- black, sticky or bloody stools;
- severe or sudden abdominal pain;
- swelling of the face, lips, tongue, hands, feet or throat;
- difficulty breathing or swallowing;
- a widespread rash, blisters, mucosal sores or peeling skin;
- chest pain, one-sided weakness or impaired speech;
- markedly reduced urination, blood in the urine or severe swelling;
- yellow skin or eyes;
- unusual bruising, bleeding, fever or repeated infections;
- an overdose.
Composition and pack
- Active ingredient: 375 mg naproxen per film-coated tablet.
- Relevant excipients: lactose monohydrate and FDC Yellow 6 – E110.
- Appearance: round orange film-coated tablets with a score line.
- Pack: two blisters containing ten tablets each.
- ATC code: M01AE02.
- EAN: 8600097416696.
- JKL: 1162423.
- Authorisation holder and manufacturer: HEMOFARM AD VRŠAC, Serbia.
- Supply status: prescription only.
Storage
Store below 25°C in the original packaging to protect it from light. Keep out of the sight and reach of children.
Naproksen HF 375 mg is available only on prescription. Medicines cannot be ordered through the online shop.
Check current availability and price for the 20-tablet pack directly with a pharmacy.
Take naproxen with or immediately after food and a full glass of water. Food may reduce local stomach irritation but does not eliminate the risk of ulcers or bleeding.
Check all pain, cold and fever medicines for ibuprofen, diclofenac, ketoprofen or another NSAID.
Tell the doctor about low-dose aspirin, anticoagulants, corticosteroids, antidepressants, diuretics and blood-pressure treatment.
Ljubica Barbulović, Master of Pharmacy
Related information
Which pain medicine is the safest?
Important: dietary supplements and topical products are not replacements for prescribed naproxen or treatments for acute gout, arthritis or another diagnosed condition.
Is Naproksen HF available without a prescription?
No. It is a prescription-only medicine.
Can the tablet be divided?
Yes. It can be divided into two equal doses.
Should it be taken with food?
Yes. It is preferably taken with or immediately after food and water.
Can it be combined with ibuprofen or diclofenac?
Not unless specifically instructed by a doctor.
Can children use this product?
This specific 375 mg product is labelled for adults.
Can it be used during pregnancy?
Only under medical advice during the first and second trimesters. It is contraindicated during the final three months.
When is urgent help required?
For vomiting blood, black stools, severe abdominal pain, breathing difficulty, facial swelling, a severe rash, chest pain or markedly reduced urination.
Sources: official patient leaflet, Summary of Product Characteristics and packaging text approved by ALIMS.
Official patient leaflet |
Summary of Product Characteristics |
Packaging text
Official text revision: August 2022. Sources checked: 3 August 2026.
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Deliveries are not made on Saturdays and Sundays.
Additional information
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Shipping cost
For the territory of the Republic of Serbia:
For goods ordered up to 5.000,00 RSD, delivery charge is 260.00 RSD (VAT included). For goods over 5.000,00 RSD, shipping is free of charge.
For international delivery:
For the export of goods abroad through the PostExport service of Post of Serbia, the shipping price is for:
- Zone I (Slovenia, Croatia, Bosnia and Herzegovina, Montenegro, Northern Macedonia) - 1,280.00 RSD
- Zone II (Other European countries) - 1,790.00 RSD
- Zone III (Asia, Africa, America, Australia and other countries) - 2,650.00 RSD
Delivery time is 15 days or more (depending on the country of delivery)
For export of goods abroad through DHL service, the shipping price is 2,700.00 RSD. Delivery time is 1-5 business days (depending on the country of delivery)
Shipping cost is with tax. The price includes the delivery of the parcel to the buyer's address with the associated tax and customs at the seller's expense. A possible additional cost may be a customs charge against the buyer, depending on the country to which the package is being shipped.
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