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Naproksen HF 375 mg film-coated tablets, 20 tablets – uses, dosage and important warnings
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- Stock: Zabrana online prodaje
- Brand: HEMOFARM-EN
- Model: BR-6056676415
Naproksen HF 375 mg film-coated tablets contain naproxen, a medicine from the group of non-steroidal anti-inflammatory drugs (NSAIDs). Naproxen relieves pain and reduces inflammation, swelling and stiffness.
According to the approved patient leaflet, the medicine is used for inflammatory and degenerative joint diseases, acute attacks of gout, painful conditions of the muscles and bones, and period pain. It is manufactured by Hemofarm AD Vršac (Serbia) and is available only on a doctor's prescription.
Important warning
- Supply status: prescription-only medicine (R).
- It must not be taken in the last three months of pregnancy, with an active or previously recurrent stomach or intestinal ulcer or bleeding, or with severe heart, liver or kidney failure.
- Like other NSAIDs, naproxen carries a slightly increased risk of heart attack and stroke, which rises with the dose and the length of treatment – the lowest effective dose should be used for the shortest possible time.
- Do not combine it with other NSAID painkillers (ibuprofen, diclofenac, acetylsalicylic acid in pain-relieving doses) without medical advice.
What Naproksen HF 375 mg is used for and how to take it
Key facts about the medicine
| Name of medicine | Naproksen HF, 375 mg, film-coated tablets |
|---|---|
| Active substance | naproxen |
| Strength | 375 mg naproxen per film-coated tablet |
| Pharmaceutical form | film-coated tablet (round, orange, with a score line) |
| Therapeutic group | non-steroidal anti-inflammatory drugs (NSAIDs) |
| Pack | carton with 2 blisters of 10 film-coated tablets (20 tablets) |
| Marketing authorisation holder / manufacturer | Hemofarm AD Vršac, Republic of Serbia |
| ALIMS authorisation number | 515-01-03425-21-001 of 30 August 2022 |
| Supply status | R – available on prescription only |
What is Naproksen HF used for?
According to the patient leaflet, Naproksen HF is used for:
- relieving inflammation, swelling, stiffness and joint pain in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis (it eases the symptoms but does not cure the disease itself);
- treating an acute attack of gout;
- painful conditions of the muscles and bones – strains, sprains and back pain;
- period (menstrual) pain.
How to take it and dosage
Always take the medicine exactly as your doctor has prescribed. Swallow the tablets with water, with or after a meal; a tablet can be divided into equal doses.
| Indication | Usual adult dose (according to the leaflet) |
|---|---|
| Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis | 500–1000 mg a day, divided into two doses 12 hours apart |
| Acute gout | 750 mg to start, then 250 mg every 8 hours until the attack has passed |
| Muscle and bone pain, period pain | 500 mg to start, then 250 mg every 6–8 hours as needed; no more than 1250 mg a day after the first day |
For elderly people and people with reduced kidney function the doctor decides the dose, which is usually lower. The leaflet gives no dosing for children. A missed dose should not be made up by taking a double dose.
Contraindications – when the medicine must not be taken
- allergy to naproxen, naproxen sodium or any of the excipients;
- hypersensitivity reactions (asthma, rash, swelling) to ibuprofen, acetylsalicylic acid or other NSAIDs;
- a current or previous ulcer or bleeding in the stomach or duodenum (two or more episodes), or intestinal bleeding or perforation related to NSAIDs;
- severe heart, liver or kidney failure;
- the last three months of pregnancy.
Warnings and precautions
Before starting treatment, tell your doctor about high blood pressure, heart, liver or kidney disease, asthma, lupus, inflammatory bowel disease, blood clotting disorders and smoking. The risk of bleeding from the digestive tract is higher in elderly people, smokers and people who drink alcohol, so alcohol is not recommended during treatment.
- Naproxen can mask the signs of an infection, such as fever and pain.
- Frequent or long-term use of painkillers for headache can make headaches worse.
- The medicine is stopped 48 hours before liver and adrenal function tests – tell the laboratory that you are taking it.
- It contains lactose and the azo colouring FDC Yellow 6 (E110), which may cause allergic reactions.
Interactions with other medicines
Tell your doctor or pharmacist about all medicines you are taking, especially: other NSAIDs and acetylsalicylic acid, anticoagulants (warfarin, heparin), corticosteroids, diuretics (e.g. furosemide), blood pressure medicines (e.g. captopril, ramipril, propranolol, losartan, candesartan), ciclosporin and tacrolimus, SSRI antidepressants, lithium, methotrexate, zidovudine, quinolone antibiotics (e.g. ciprofloxacin), probenecid, bisphosphonates, phenytoin, sulphonamides, sulphonylureas (e.g. glibenclamide, gliclazide) and digoxin. NSAIDs should not be taken for 8–12 days after mifepristone, and with colestyramine naproxen is taken 1 hour before or 4–6 hours after it.
Pregnancy, breast-feeding and fertility
- First and second trimester: only after talking to your doctor.
- Last three months of pregnancy: the medicine must not be used.
- Breast-feeding: use is not recommended.
- Fertility: the medicine may make it harder to conceive – women planning a pregnancy or being investigated for infertility should talk to their doctor.
Driving and using machines
Naproxen can cause dizziness, drowsiness, tiredness and visual disturbances. If this happens, do not drive or operate machinery.
Possible side effects
Common side effects (up to 1 in 10 people) include nausea, vomiting, diarrhoea, stomach pain, headache, dizziness, drowsiness, confusion, visual disturbances, ringing in the ears, rash, itching and tiredness. Rarely, changes in blood counts, allergic reactions and inflammation of the liver may occur, and very rarely inflammation of the kidneys or pancreas, severe skin reactions and seizures. Fluid retention and raised blood pressure have also been reported with medicines of this group (NSAIDs). Side effects can be reported to ALIMS, the Serbian Medicines and Medical Devices Agency.
Overdose
Signs of an overdose may include headache, nausea, vomiting, stomach pain, bleeding from the stomach or intestines, disorientation, drowsiness, ringing in the ears and loss of consciousness. If you have taken more tablets than prescribed, contact a doctor or the nearest healthcare facility straight away and take the medicine pack with you.
When to seek medical help immediately
- black or bloody stools, vomiting blood or material that looks like coffee grounds, severe stomach pain;
- swelling of the face, lips, tongue or throat, difficulty breathing or swallowing;
- a severe rash with blisters or peeling skin;
- chest pain, sudden weakness on one side of the body or difficulty speaking.
Pharmacist's advice
Take naproxen with a meal or straight after one, with a full glass of water – this reduces irritation of the stomach. Do not combine it on your own with other painkillers, including those sold without a prescription, because many of them contain ibuprofen or acetylsalicylic acid.
If you use the medicine for a longer period, agree regular checks of your blood pressure, blood count and kidney function with your doctor, and report any black stools or stomach pain immediately.
Availability and price
Naproksen HF 375 mg is dispensed only on a doctor's prescription, in a pharmacy. This page is for information purposes only and is not an offer to sell the medicine online.
For questions about your treatment, please speak to your doctor or to the pharmacist at your pharmacy.
Composition, pack and manufacturer
- Active substance: naproxen 375 mg per film-coated tablet.
- Excipients (tablet core): povidone K 30, maize starch, lactose monohydrate, talc, magnesium stearate, croscarmellose sodium, FDC Yellow 6 (E110).
- Film coating (Opadry White YS-1-7002): hypromellose, titanium dioxide (E171), macrogol 8000, FDC Yellow 6 (E110).
- Pack: Al/PVC blister of 10 film-coated tablets; each carton contains 2 blisters (20 tablets) and a patient leaflet.
- Marketing authorisation holder and manufacturer: Hemofarm AD Vršac, Beogradski put bb, Vršac, Serbia.
Storage
- Store below 25 °C in the original package in order to protect from light.
- Keep out of the sight and reach of children; do not use after the expiry date stated on the pack.
- Return unused medicine to a pharmacy – do not throw it into wastewater or household waste.
Frequently asked questions
What is the maximum daily dose of naproxen for muscle pain or period pain?
According to the leaflet, the starting dose is 500 mg, followed by 250 mg every 6–8 hours as needed, with no more than 1250 mg a day after the first day. One Naproksen HF tablet contains 375 mg, so the exact schedule is set by the doctor.
Should Naproksen HF be taken before or after food?
The tablets are taken with or after a meal, with water, which reduces stomach irritation.
Can I take Naproksen HF together with ibuprofen or aspirin?
Not without medical advice. Using several NSAIDs at the same time increases the risk of stomach and intestinal bleeding and other side effects.
Can the medicine be used during pregnancy?
It must not be used in the last three months of pregnancy, and in the first two trimesters only if the doctor considers it necessary. It is not recommended while breast-feeding.
Sources
Sources checked on: 6 November 2026.
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Additional information
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