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Myderison 50 mg and 150 mg – tolperisone for post-stroke spasticity
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- Stock: Zabrana online prodaje
- Brand: GOODWILL PHARMA-EN
- Model: BR-605654177
Myderison 50 mg and 150 mg are prescription medicines containing tolperisone hydrochloride. Tolperisone is a centrally acting muscle relaxant used for the symptomatic treatment of pathologically increased muscle tone, or spasticity, following a stroke in adults.
Myderison is available only with a medical prescription. The only approved indication for tolperisone is the symptomatic treatment of post-stroke spasticity in adults. It is not approved for ordinary muscle cramps, a stiff neck, back pain, a slipped disc, lumbago, spondylosis or recovery after orthopaedic surgery.
Myderison 50 mg and 150 mg – use, dosage and warnings
| Information | Myderison 50 mg | Myderison 150 mg |
|---|---|---|
| Active substance | 50 mg tolperisone hydrochloride | 150 mg tolperisone hydrochloride |
| Dosage form | Film-coated tablet marked “50” | Film-coated tablet marked “150” |
| Pack size | 30 tablets – 2 blisters of 15 | 30 tablets – 3 blisters of 10 |
| Approved indication | Symptomatic treatment of post-stroke spasticity in adults | |
| Legal status | Prescription-only medicine | |
What is Myderison used for?
Spasticity is an abnormal increase in muscle tone that may cause stiffness, restricted movement, abnormal limb positioning and reduced ability to perform everyday activities. It may develop following damage to the central nervous system caused by a stroke.
Myderison may reduce spasticity, but it does not treat all consequences of a stroke and does not replace physiotherapy, occupational therapy, prescribed exercises, neurological monitoring or other prescribed treatment.
How is Myderison taken?
Take the medicine exactly as prescribed by the doctor. The usual total daily dose for adults is 150–450 mg, divided into three individual doses. The doctor determines the tablet strength and exact dose according to the patient’s needs and tolerance.
Take the tablets after a meal with a sufficient amount of water. The effect of tolperisone may be reduced if it is taken without food or with an insufficient amount of food.
Do not independently increase or reduce the dose or change the combination of 50 mg and 150 mg tablets.
Children and adolescents
The safety and efficacy of tolperisone in children and adolescents have not been established. A medicine prescribed for an adult must not be given to a child.
Kidney or liver impairment
Patients with moderate kidney or liver impairment require individual dose adjustment and more frequent monitoring of the affected organ.
Tolperisone is not recommended in patients with severe kidney or liver impairment.
Who must not take Myderison?
- people allergic to tolperisone hydrochloride;
- people allergic to the chemically related substance eperisone;
- people allergic to any of the other ingredients;
- patients with myasthenia gravis;
- women who are pregnant;
- women who are breastfeeding;
- patients who have previously experienced hypersensitivity to tolperisone.
Myderison contains lactose. People with an intolerance to certain sugars should consult their doctor before taking the medicine.
Hypersensitivity reactions
The most important safety risk associated with tolperisone is hypersensitivity. Reactions may be limited to mild skin symptoms but may progress to a serious systemic reaction or anaphylactic shock.
The risk may be higher in women, older patients, people using several medicines, particularly non-steroidal anti-inflammatory medicines, and patients with asthma, hay fever, atopic dermatitis, hives or another allergic condition.
People allergic to lidocaine may have an increased risk of cross-hypersensitivity to tolperisone.
- redness, rash, hives or severe itching;
- swelling of the face, lips, tongue or throat;
- difficulty swallowing or breathing;
- wheezing;
- a rapid heartbeat;
- a marked fall in blood pressure, weakness or loss of consciousness.
Interactions with other medicines
Tell the doctor and pharmacist about all medicines being used. Tolperisone may increase the concentration or effect of certain medicines, including:
- thioridazine and perphenazine;
- tolterodine;
- venlafaxine and desipramine;
- atomoxetine;
- dextromethorphan;
- metoprolol and nebivolol.
When tolperisone is used with another centrally acting muscle relaxant, the doctor may consider reducing the dose.
Tolperisone may increase the effect of niflumic acid. A dose adjustment may be required when it is combined with niflumic acid or another non-steroidal anti-inflammatory medicine.
Pregnancy and breastfeeding
According to the approved patient leaflet, Myderison should not be used during pregnancy or breastfeeding. A patient who becomes pregnant or plans a pregnancy should contact the prescribing doctor.
Driving and using machines
Tolperisone has a low potential to cause sedation. However, do not drive or operate machinery if dizziness, drowsiness, impaired attention, blurred vision, a seizure or muscle weakness occurs.
Possible side effects
Uncommon side effects may include reduced appetite, sleep disorders, dizziness, drowsiness, headache, low blood pressure, nausea, diarrhoea, dry mouth, indigestion, abdominal discomfort, muscle weakness, muscle or limb pain, weakness and fatigue.
Rare effects include hypersensitivity, impaired attention, tremor, abnormal skin sensations, seizures, blurred vision, tinnitus, a rapid or irregular heartbeat, breathing difficulties, constipation, vomiting, rash, itching, hives and changes in liver laboratory tests.
Very rare effects include anaemia, enlarged lymph nodes, confusion, anaphylactic shock, a slow heartbeat and increased blood creatinine.
Overdose and missed dose
An overdose may cause drowsiness, nausea, vomiting, upper abdominal pain, a rapid heartbeat, high blood pressure, slowed movement and dizziness. Seizures, slowed or stopped breathing and coma have been reported in severe cases.
Seek urgent medical help if too much medicine has been taken. There is no known specific antidote.
Do not take a double dose to make up for a forgotten tablet. Take the next dose at the usual time.
Myderison is not a general medicine for painful or cramped muscles. Its approved use is limited to post-stroke spasticity in adults. In these patients, it should form only one part of a broader rehabilitation plan supervised by a neurologist, rehabilitation physician and physiotherapist. Pay particular attention to rash, itching, swelling or breathing difficulties, because tolperisone must not be used again after an allergic reaction.
Ljubica Barbulović, Master of Pharmacy
Availability and price
Similar medicine containing tolperisone
Mydocalm also contains tolperisone. Mydocalm and Myderison must not be exchanged without medical advice or taken together. The doctor and pharmacist determine the appropriate medicine, strength and dose.
Health monitoring after a stroke
Blood-pressure monitoring is often an important part of follow-up after a stroke. The blood pressure monitors category includes devices intended for home monitoring. Measurement frequency and target values should be agreed with the doctor.
Monitoring devices do not replace Myderison, prescribed treatment or professionally supervised rehabilitation.
Composition, appearance and packaging
Each Myderison 50 mg film-coated tablet contains 50 mg of tolperisone hydrochloride. Each Myderison 150 mg film-coated tablet contains 150 mg of tolperisone hydrochloride.
The tablet core contains talc, stearic acid, crospovidone, betaine hydrochloride, mannitol and microcrystalline cellulose. The film coating contains titanium dioxide, macrogol/PEG 4000, hypromellose and lactose monohydrate.
The tablets are white and round. One side is marked “50” or “150”, while the other side bears the manufacturer’s logo.
Marketing authorisation holder: Goodwill Pharma d.o.o. Subotica.
Storage
Keep out of the sight and reach of children. Store below 30°C in the original packaging. Do not use after the expiry date stated on the pack.
Frequently asked questions
Can Myderison be used for back pain?
No. Back pain, a slipped disc and spondylosis are not approved indications for tolperisone. Myderison is approved for post-stroke spasticity in adults.
What is the difference between Myderison 50 mg and 150 mg?
Both strengths contain the same active substance but provide different amounts of tolperisone per tablet. The doctor determines the appropriate strength and combination.
Should Myderison be taken before or after food?
Take it after a meal with a glass of water. Taking it without sufficient food may reduce its effect.
Does Myderison cause drowsiness?
Tolperisone has a low potential to cause sedation, although some patients may experience drowsiness, dizziness or impaired attention.
Official sources:
ALIMS – Myderison 50 mg Patient Leaflet |
ALIMS – Myderison 150 mg Patient Leaflet |
ALIMS – Summary of Product Characteristics.
Marketing authorisation numbers: 515-01-00767-21-001 and 515-01-00768-21-001, dated 11 April 2022. Content updated: July 2026.
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