5-MTHF 1 mg 60 Capsules – Active Methylfolate for Blood Formation, Cell Division and Preconception Support

• 1 mg of L-5-methyltetrahydrofolate per capsule,
• active form of vitamin B9,
• Extrafolate-S® branded ingredient,
• folate contributes to normal blood formation,
• contributes to normal homocysteine metabolism,
• has a role in cell division,
• contributes to normal amino-acid synthesis,
• contributes to maternal tissue growth during pregnancy,
• contributes to the reduction of tiredness and fatigue,
• single-ingredient formula without added iron or vitamin B12,
• vegetable capsule,
• approximately a 60-day supply.

• in confirmed or reasonably suspected inadequate folate status,
• when an active folate form has been professionally recommended,
• during preconception and early pregnancy under gynaecological guidance,
• when increased folate needs have been medically assessed,
• for nutritional support of normal blood formation and homocysteine metabolism,
• when a single-ingredient product without added iron is preferred.

Having an MTHFR gene variant does not automatically mean that high-dose methylfolate is required. The form and amount should be selected according to diet, laboratory results, pregnancy needs and other supplements.

5-MTHF is a dietary supplement and not a medicine for anaemia, depression, infertility, neuropathy, elevated homocysteine or another medical condition.

One capsule provides 1,000 µg of active folate. This is higher than the general recommendation of 400 µg of folic acid daily for most women who may become pregnant. Use during preconception and pregnancy should be agreed with a gynaecologist.

Women at increased risk of a neural-tube defect may be prescribed a substantially higher folic-acid dose. This is a medical recommendation and should not be independently replaced with methylfolate.

Vitamin B12 status should be considered before prolonged high-dose folate use. Folate can improve blood-count abnormalities while neurological consequences of vitamin B12 deficiency remain unrecognised.

Consult a doctor before use with methotrexate, antiepileptic medicines, trimethoprim, sulfasalazine, chemotherapy or other medicines affecting folate metabolism.

Do not automatically combine it with prenatal vitamins, B-complex products, multivitamins or other folic-acid or methylfolate supplements without checking the total intake.

The product is not a complete prenatal supplement because it does not provide vitamin B12, iron, iodine, vitamin D, choline, DHA or other nutrients that may be required during pregnancy.

Mild gastrointestinal discomfort, headache or an individual hypersensitivity reaction may occur. Stop use in cases of a rash, swelling or another pronounced reaction.

The product is not intended for children without paediatric advice.

Check the labels of all prenatal, multivitamin and B-complex products before starting. Folate is commonly present in several supplements, so the total daily intake can easily be duplicated.

Fatigue, pallor, palpitations, tingling, balance problems or an abnormal blood count should not automatically be attributed to low folate. Folate and vitamin B12 deficiency can cause overlapping symptoms but require different management.

Women planning pregnancy should discuss folate before a positive pregnancy test. However, a 1 mg methylfolate capsule is not automatically the appropriate dose for every woman.

Ljubica Barbulović, Master of Pharmacy

Read more about preconception planning, ovulation and timely professional advice: Female fertility and ovulation.

What is 5-MTHF?
It is L-5-methyltetrahydrofolate, a biologically active form of folate or vitamin B9.

How much folate does one capsule contain?
One capsule contains 1 mg, or 1,000 µg, of L-5-methyltetrahydrofolate.

How is it taken?
According to the local declaration, take one capsule daily, preferably with a meal.

How long does one pack last?
At one capsule daily, a pack of 60 capsules lasts approximately 60 days.

Is 5-MTHF the same as folic acid?
Both are vitamin B9 forms. 5-MTHF is active folate, whereas folic acid undergoes metabolic conversion.

Is methylfolate required for an MTHFR variant?
Not automatically. Common MTHFR variants do not by themselves establish a need for high-dose methylfolate.

Can it be used when planning pregnancy?
It may be used when active folate has been recommended, but the 1 mg dose should be agreed with a gynaecologist.

Is it a complete prenatal supplement?
No. It provides active folate only.

Can it be combined with vitamin B12?
Yes when appropriate, but the combination should reflect laboratory results and other supplements.

Can it be used for anaemia?
Only after identifying the cause because anaemia may result from iron, folate or vitamin B12 deficiency, bleeding or another condition.