TRITTICO RETARD

Trittico Retard 150 mg is a medicine containing the active substance trazodone hydrochloride. It belongs to the antidepressant group and is used in adults to treat depressive disorders with or without anxiety, including depression accompanied by sleep disturbances.

Trittico Retard is a prolonged-release tablet. The active substance is released gradually, so the medicine must be taken exactly according to the schedule prescribed by the doctor. It is not an ordinary sleeping product and should not be started independently solely because of insomnia.

Trittico Retard 150 mg – what is it used for and how should it be taken?

What is Trittico Retard used for?

The medicine is intended for the treatment of depressive disorders in adults, including depression:

• with or without anxiety;
• accompanied by difficulty falling asleep;
• accompanied by frequent night-time awakening or another sleep disturbance;
• associated with reduced mood, energy and everyday functioning.

Trittico Retard is not intended for patients under 18 years of age. It is not a supplement for stress and should not be used occasionally when needed.

How should Trittico Retard be taken?

The doctor determines the dose according to the type and severity of symptoms, age, general health, treatment tolerability and other medicines being taken.

• Treatment is generally started in the evening, with gradual dose adjustment.
• The medicine may be taken on an empty stomach or after food.
• Swallow the tablet with sufficient water.
• The tablet has two score lines and can be divided into three equal parts.
• Use divided portions only if this dosing schedule has been prescribed.
• Take the medicine at approximately the same time every day.
• Do not increase the dose because of one sleepless night or a temporary deterioration in mood.

The usual initial daily dose in adults may be 75–150 mg, generally administered as a single evening dose. The doctor may gradually increase the dose when necessary. This information is not an instruction for self-dosing.

If a dose is missed: take the next dose at the usual time. Do not take a double dose.

When should Trittico Retard not be taken?

Do not take the medicine:

• if you are allergic to trazodone or any of the other ingredients;
• after excessive alcohol consumption;
• if you are dependent on hypnotic medicines;
• shortly after a myocardial infarction;
• if you are under 18 years of age;
• during pregnancy or breastfeeding without an individual medical assessment.

Special warnings and precautions

Before starting treatment, tell the doctor if you have:

• epilepsy or previous seizures;
• liver or kidney disease;
• heart disease, an abnormal heart rhythm or prolonged QT interval;
• low blood pressure or fainting when standing up;
• hyperthyroidism;
• difficulty urinating or an enlarged prostate;
• angle-closure glaucoma;
• schizophrenia, bipolar disorder or another psychiatric condition;
• a history of suicidal thoughts, self-harm or a suicide attempt.

Older people may be more sensitive to drowsiness, dizziness and a fall in blood pressure when standing up. Rise slowly from a bed or chair.

Suicidal thoughts and behavioural changes

Depression itself is associated with a risk of suicidal thoughts and self-harm. The risk may remain present or temporarily increase at the beginning of treatment before the full effect of the medicine develops.

The patient, family member or caregiver should immediately contact a doctor if they notice:

• worsening depression or anxiety;
• suicidal thoughts or plans to self-harm;
• unusual aggression, irritability or agitation;
• a sudden change in behaviour;
• manic behaviour, marked euphoria or a greatly reduced need for sleep.

Interactions with medicines and supplements

Tell the doctor about all medicines, herbal products and food supplements. Important interactions include:

• other antidepressants and medicines that increase serotonin activity;
• monoamine oxidase inhibitors;
• tricyclic antidepressants;
• fluoxetine and other serotonergic medicines;
• antipsychotics, sedatives, hypnotics and anxiolytics;
• sedating antihistamines;
• medicines that prolong the QT interval;
• erythromycin, ketoconazole, itraconazole, ritonavir and other CYP3A4 inhibitors;
• carbamazepine, phenytoin and barbiturates;
• warfarin, anticoagulants and antiplatelet medicines;
• blood-pressure-lowering medicines;
• digoxin, clonidine and levodopa.

Do not independently combine trazodone with St John’s wort, 5-HTP, tryptophan or SAM-e. These combinations may increase serotonergic activity and the risk of serious adverse reactions.

Alcohol and driving

Alcohol increases the sedative effects of trazodone and should be avoided during treatment.

The medicine may cause drowsiness, sedation, dizziness, confusion or blurred vision. Do not drive or operate machinery until you know how it affects you.

Pregnancy and breastfeeding

Trittico Retard may be used during pregnancy or breastfeeding only when the doctor considers treatment necessary and under strict medical supervision.

Do not stop treatment independently after learning that you are pregnant. Abrupt discontinuation of psychiatric treatment may also involve risks, so the decision must be made by a doctor.

Possible side effects

The frequency of individual adverse effects cannot always be estimated precisely. Possible effects include:

• drowsiness, sedation, fatigue or dizziness;
• headache, tremor or reduced attention;
• blurred vision;
• nausea, vomiting, dry mouth or constipation;
• diarrhoea, abdominal pain or indigestion;
• low blood pressure, particularly when standing up;
• a fast, slow or irregular heartbeat;
• changes in appetite or body weight;
• insomnia, nervousness, agitation or nightmares;
• changes in sexual desire;
• rash and allergic reactions;
• changes in blood-cell counts, liver function or blood sodium levels.

Serotonin syndrome

Serotonin syndrome is a potentially dangerous reaction that may occur particularly when trazodone is combined with other serotonergic medicines or supplements. Signs may include agitation, confusion, hallucinations, a rapid heartbeat, sweating, diarrhoea, high temperature and muscle spasms or twitching.

If more medicine has been taken than prescribed

An overdose may cause pronounced drowsiness, vomiting, dizziness, abnormal heart rhythm, breathing difficulties, seizures, low blood pressure or serotonin syndrome. Symptoms may be delayed for several hours.

Contact emergency medical services or the nearest hospital immediately and take the medicine pack with you. Do not wait for symptoms to appear.

How to store Trittico Retard

• Keep out of the sight and reach of children.
• Store below 25°C.
• Keep in the original packaging.
• Do not use after the expiry date.
• Return unused medicine to a pharmacy that collects pharmaceutical waste.

Composition

Each prolonged-release tablet contains 150 mg of trazodone hydrochloride, equivalent to 136.6 mg of trazodone.

The other ingredients are carnauba wax, magnesium stearate, povidone and sucrose. Patients with an intolerance to certain sugars should consult a doctor before use.

Official sources:

• ALIMS – Patient Information Leaflet for Trittico Retard 150 mg
• ALIMS – Summary of Product Characteristics for Trittico Retard 150 mg

The patient information leaflet and Summary of Product Characteristics were last approved in December 2025. Information prepared on 1 August 2026.