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Progestogel 10 mg/g gel (progesterone) – premenstrual breast pain (mastodynia)
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- Stock: Zabrana online prodaje
- Brand: BIESSEN PHARMA products
- Model: BR-1671610044
Progestogel is a gel for use on the skin containing natural progesterone 10 mg/g (1 g progesterone per 100 g gel). Progesterone is a physiological female hormone from the progestogen group.
The gel is applied to the skin of the breasts for premenstrual breast pain (essential premenstrual mastodynia), provided there are no pathological changes in the breast tissue. That is why a medical examination to exclude a hormone-dependent tumour is carried out before treatment. The pack contains an 80 g tube and a graduated applicator for accurate dosing.
Important warning
- Supply status in Serbia: prescription-only medicine.
- Must not be used with breast cancer or allergy to progesterone or the excipients; a medical examination is required before starting treatment.
- For external use only – must not be swallowed; do not apply to injured skin.
- Progestogel has no contraceptive effect; it is not intended for men and is not recommended during pregnancy and breastfeeding.
- This page is for information only and is not an offer to buy the medicine online.
What is Progestogel gel used for and how is it correctly applied to the breasts?
Key facts about the medicine
| Name of the medicine | Progestogel®, 10 mg/g, gel |
|---|---|
| Active substance | progesterone |
| Strength | 10 mg progesterone per 1 g gel (1 g/100 g) |
| Pharmaceutical form | gel for cutaneous use (colourless to slightly opalescent, smells of alcohol) |
| Therapeutic group | sex hormones – pregnene derivatives (ATC G03DA04) |
| Pack | 80 g aluminium tube with graduated dosing applicator |
| Marketing authorisation holder | Biessen Pharma d.o.o. Belgrade; manufacturer Delpharm Drogenbos SA, Belgium |
| Supply status (Serbia) | prescription-only medicine |
What is Progestogel used for?
According to the official leaflet, Progestogel is used for premenstrual breast pain (essential premenstrual mastodynia), provided there are no pathological changes in the breast tissue.
Premenstrual mastodynia is pain, tension and tenderness of the breasts occurring in the second half of the cycle, before menstruation. New lumps, skin changes on the breast, nipple discharge or pain unrelated to the cycle are not an indication for using the gel on your own – they must be examined by a doctor.
How is it used and dosed?
| Parameter | According to the leaflet |
|---|---|
| Period of use | from day 10 to day 25 of the menstrual cycle |
| Daily dose | 5 g gel per day – 2.5 g on each breast |
| Maximum daily dose | 5 g |
| Method of use | cutaneous, after showering, using the dosing applicator, gently rubbing in until absorbed |
| Duration | may be used for a longer period, with medical check-ups every three months |
- Squeeze the gel evenly from the tube into the groove of the dosing applicator up to the 2.5 g mark.
- Breasts and hands must be clean during application.
- Do not apply the gel to injured skin – absorption of progesterone is then increased.
- If the cycle is irregular, the doctor may recommend a combination with oral progesterone or a progestin.
Special patient groups
- Men: the medicine is not intended for use in men.
- Pregnant and breastfeeding women: use is not recommended.
Contraindications – when the medicine must not be used
Do not use Progestogel:
- if you are allergic to progesterone or any of the excipients;
- if you have breast cancer.
Precautions and warnings
- A medical examination is needed before treatment to exclude a hormone-dependent tumour (e.g. breast cancer).
- For external use only – do not swallow.
- This treatment has no contraceptive effect.
- A risk of side effects in another person after direct contact with skin where the gel was applied cannot be excluded.
- On injured skin there is a risk of increased progesterone absorption and systemic side effects – use is not recommended.
- The gel contains macrogolglycerol hydroxystearate, which may cause skin reactions; it also contains ethanol.
Interactions with other medicines, alcohol and food
The leaflet does not list specific interactions, but tell your doctor or pharmacist about all medicines you use, including hormonal products and medicines applied to the skin of the breasts.
Pregnancy and breastfeeding
Use of Progestogel during pregnancy and breastfeeding is not recommended. If you are pregnant, breastfeeding or planning a pregnancy, ask your doctor. The gel does not protect against pregnancy.
Driving and using machines
Not applicable – the medicine does not affect the ability to drive and use machines.
Possible side effects
- Most common side effect: earlier onset of menstruation (1–2 days earlier), without change in the amount of bleeding.
- Isolated cases of hypersensitivity or non-specific skin irritation.
- When applied to injured skin, the risk of systemic effects increases: menstrual changes, absence of periods (amenorrhoea), breakthrough bleeding and headache.
Because of the way it is applied, systemic exposure to progesterone is unlikely under the recommended conditions of use. Report suspected side effects to your doctor, pharmacist or ALIMS.
Overdose, missed dose and stopping treatment
- Too much gel: if you have used more than you should, tell your doctor or pharmacist.
- Missed dose: do not use a double dose; continue as prescribed by your doctor.
- Stopping: agree with your doctor on the duration of treatment and the three-monthly check-ups.
When to seek medical help immediately?
- a new lump or thickening in the breast, retraction of the nipple or skin, nipple discharge
- marked redness, swelling or blisters on the skin where the gel was applied
- swelling of the face, lips or throat, difficulty breathing (allergic reaction)
- unusual bleeding or absence of periods with suspected pregnancy
Pharmacist's advice
Apply the gel after showering to clean, dry breast skin, only from day 10 to day 25 of the cycle – mark the dates in a calendar. Rub it in gently until fully absorbed and wash your hands afterwards; avoid direct skin contact of your partner or children with the treated area until the gel has been absorbed.
Do not apply it to scratches or irritated or injured skin. Use an opened tube within 30 days. Regular breast self-examination and doctor check-ups every three months are part of the treatment – pain unrelated to the cycle or a new lump requires examination.
Availability and price
Progestogel is a prescription-only medicine. Under Serbian regulations medicines are not sold online – this page is for information only.
Please check availability and price in a pharmacy.
Composition, packaging and manufacturer
- Active substance: progesterone – 100 g gel contains 1 g progesterone.
- Excipients: octyldodecanol, carbomer 980, macrogolglycerol hydroxystearate, trolamine, ethanol 96%, purified water.
- Appearance: colourless or slightly opalescent gel smelling of alcohol, free of crystals.
- Pack: aluminium tube with 80 g gel closed with a white cap, and a graduated polystyrene dosing applicator.
- Marketing authorisation holder: Biessen Pharma d.o.o. Belgrade, Rudnička 9; manufacturer: Delpharm Drogenbos SA, Drogenbos, Belgium. Authorisation number: 515-01-02907-20-002 of 22 September 2021.
Storage
- Keep out of the sight and reach of children.
- No special storage conditions.
- Shelf life after first opening: 30 days, below 25 °C.
- Do not use after the expiry date; return unused medicine to a pharmacy.
Frequently asked questions
On which days of the cycle is Progestogel applied?
According to the leaflet, from day 10 to day 25 of the menstrual cycle, once daily 5 g gel – 2.5 g on each breast, using the dosing applicator. The maximum daily dose is 5 g.
Does Progestogel protect against pregnancy?
No. The leaflet states clearly that this treatment has no contraceptive effect. Use during pregnancy and breastfeeding is not recommended.
Do I need an examination before using the gel?
Yes. Before treatment the doctor must exclude a hormone-dependent tumour, such as breast cancer. The gel is used only when there are no pathological changes in the breast tissue, and check-ups are recommended every three months.
What is the most common side effect?
The most common is an earlier start of menstruation, 1–2 days early, without change in the amount of bleeding. Skin irritation or hypersensitivity is rare.
Related information
For additional care and support with premenstrual symptoms, see also the PMS category – products in this category do not replace the medicine you have been prescribed.
Sources
- ALIMS – Patient Information Leaflet Progestogel 10 mg/g gel (September 2021, in Serbian)
- ALIMS – Summary of Product Characteristics Progestogel 10 mg/g gel (in Serbian)
Sources checked on: 23 October 2026.
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