Efferalgan 500 mg effervescent tablets – for pain and fever

Efferalgan 500 mg effervescent tablets contain 500 mg paracetamol per tablet. Paracetamol is an analgesic and antipyretic that relieves pain and reduces fever.

The tablet is dissolved in a glass of water before use. According to the leaflet approved by ALIMS, this form is intended for adults and children over 12 (body weight above 40 kg).

What is the Efferalgan 500 mg effervescent tablet used for and how is it dosed correctly?

Key facts about the medicine

What is the Efferalgan 500 mg effervescent tablet used for?

According to the patient leaflet, Efferalgan 500 mg effervescent tablets are used to relieve mild to moderately severe pain and/or fever in adults and children over 12.

For younger children there are other forms and strengths of paracetamol, which you should discuss with a doctor or pharmacist.

How is it used and dosed?

The dose is based on body weight. Usual dosage according to the leaflet:

• Usually no more than 3 g (6 tablets) a day is needed; up to 4 g a day only for more severe pain and on a doctor's recommendation.
• Method of administration: dissolve the whole tablet in a full glass of water and drink immediately; do not swallow or chew the tablet.
• In children, doses should preferably be given every 6 hours, including at night (at least 4 hours apart).
• Duration: do not use for more than 3 days in a row without medical advice.

Special patient groups

• Children under 12 (below 41 kg): this form is not intended for them; use other forms of paracetamol on the advice of a doctor or pharmacist.
• Adults under 50 kg, mild to moderate liver impairment, Gilbert's syndrome, chronic alcoholism, chronic malnutrition or dehydration: no more than 60 mg/kg a day and no more than 3 g a day.
• Kidney impairment: at least 6 hours between doses (creatinine clearance above 10 ml/min) or 8 hours (below 10 ml/min); a total of no more than 3 g (6 tablets) a day unless the doctor decides otherwise.

Contraindications – when the medicine must not be used

• hypersensitivity (allergy) to paracetamol or any of the excipients
• severe liver disease

Precautions and warnings

• Ask your doctor or pharmacist before use if you are an adult weighing under 50 kg, have liver or kidney disease, Gilbert's syndrome, G6PD deficiency, drink 3 or more alcoholic drinks a day, are malnourished, have an eating disorder or are dehydrated.
• If you have or develop acute viral hepatitis during treatment, tell your doctor – they may stop the treatment.
• Check that other medicines you take (prescription or non-prescription) do not contain paracetamol, especially in children.
• Sodium: 412 mg per tablet, about 20.6% of the maximum recommended daily intake for adults; tell your doctor if you need several tablets a day for a long time, especially on a low-salt diet.
• Sorbitol: 300 mg per tablet (a source of fructose); sodium benzoate (E211): 61 mg per tablet.
• If pain or fever lasts more than 3 days, does not improve or new symptoms appear, stop self-treatment and see a doctor.

Interactions with other medicines, alcohol and food

• Oral anticoagulants: high doses of paracetamol may enhance their effect; your doctor may adjust the anticoagulant dose.
• Flucloxacillin: increased risk of metabolic acidosis, especially with severe kidney impairment, sepsis, malnutrition or chronic alcoholism.
• Laboratory tests: tell your doctor you are using the medicine if uric acid or blood sugar tests are planned.

Tell your doctor or pharmacist about all medicines you are taking, have recently taken or might take.

Pregnancy and breastfeeding

If you are pregnant, think you may be pregnant, are planning a pregnancy or are breastfeeding, ask your doctor or pharmacist before use. If necessary, the medicine may be used during pregnancy and breastfeeding only under medical supervision, at the lowest effective dose for the shortest possible time. Paracetamol may affect female fertility; the effect is reversible after stopping.

Driving and using machines

According to the leaflet, paracetamol has no or negligible influence on the ability to drive and use machines.

Possible side effects

• Rare: rash or skin redness and allergic reactions such as sudden swelling of the face and neck or sudden weakness with a drop in blood pressure – stop use, contact a doctor and never take paracetamol-containing medicines again.
• Very rare: severe skin reactions; changes in blood tests requiring monitoring – liver function disorder, low white blood cell or platelet count (may show as nosebleeds or bleeding gums).
• Reported, frequency not stated: diarrhoea, abdominal pain, raised liver enzymes and increased or decreased INR values.

Suspected side effects can be reported to your doctor, pharmacist or the Medicines and Medical Devices Agency of Serbia (ALIMS).

Overdose, missed dose and stopping treatment

• Overdose: nausea, vomiting, loss of appetite, marked pallor and abdominal pain usually appear within the first 24 hours; delayed severe liver damage may occur. Seek medical help immediately, even without symptoms.
• Missed dose: do not take a double dose to make up for a missed one.
• Stopping treatment: the medicine is taken only while pain or fever persist.

Related information

• How to bring down a fever quickly?
• Which is the safest pain reliever?

For additional care and support with fever, see also the Digital thermometers category – products in this category do not replace the medicine you have been prescribed.

Composition, packaging and manufacturer

• One effervescent tablet contains 500 mg paracetamol.
• Excipients: anhydrous citric acid, anhydrous sodium carbonate, sodium hydrogen carbonate, sorbitol, saccharin sodium (E954), docusate sodium, povidone, sodium benzoate (E211).
• Pack: Al/PE strip with 4 effervescent tablets; carton with 4 strips (16 tablets) and a leaflet.
• Marketing authorisation holder: Amicus SRB d.o.o., Belgrade (authorisation 515-01-02874-22-001 of 22.05.2023).
• Manufacturer: UPSA SAS, Agen or Le Passage, France.

Storage

• This medicine does not require any special storage conditions.
• Keep out of the sight and reach of children; do not use after the expiry date stated on the pack.
• Return unused medicine to a pharmacy that collects unused medicines; do not dispose of it via wastewater or household waste.

Frequently asked questions

How many Efferalgan 500 effervescent tablets can I take a day?

Adults and children over 50 kg: 1–2 tablets, at least 4 hours apart; usually no more than 6 tablets (3 g) a day, and up to 8 tablets (4 g) only on a doctor's recommendation. Children weighing 41 to 50 kg: 1 tablet, no more than 6 a day.

Can I swallow the effervescent tablet without water?

No. The tablet is dissolved in a full glass of water and drunk immediately; it should not be swallowed or chewed.

Can people with high blood pressure use Efferalgan effervescent tablets?

One tablet contains 412 mg sodium. People who need to limit their salt intake should ask a doctor before longer use or taking several tablets a day.

Can Efferalgan be used during pregnancy?

Only if necessary, under medical supervision, at the lowest effective dose for the shortest possible time.

Sources

• ALIMS – Patient leaflet Efferalgan, 500 mg, effervescent tablets (authorisation 515-01-02874-22-001, 22.05.2023, revision May 2023)

Sources checked on: 23 October 2026.