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Product Description

Botofill cream is recommended as a night care for the face when the facial muscles are relaxed during the night and the use of argireline hexapeptide is sufficient.

Botofill serum gel is recommended as a daily facial care when stronger relaxants such as SNAP-8 octapetide are desired due to increased daily muscle activity.

BOTOFILL cream & serum gel contains innovative cosmetically active ingredients with Botox effect - ARGIRELIN hexapeptide and SNAP-8 octapeptide in maximum recommended concentrations of 10%.

ARGIRELIN AND SNAP-8 - peptides with a mechanism of action such as Botulinum Toxin:

  • They act directly on the muscle contraction which is the cause of wrinkles.
  • When applied to the skin, they lead to the relaxation of the muscles responsible for the formation of mimic wrinkles.

When moving the face, the facial muscles contract (spasm). Frequent repetition of the same movements leads to wrinkling of the skin and the formation of wrinkles. These are the so-called mimic wrinkles caused by facial expressions. Muscle contractions occur when nerve cells secrete neurotransmitters into the synaptic space (the space between the nerve and the muscle cell), which then act directly on the muscle cells, causing the muscles to contract. The protein SNARE complex located in the nerve cell is responsible for releasing the neurotransmitter into the synaptic space and causing muscle contraction.Botulinum toxin works by breaking down SNAP-25 proteins from the SNARE complex, thus preventing the secretion of neurotransmitters and blocking muscle contraction, which causes muscle paralysis and tightening of facial skin.Argireline hexapeptide binds to the SNARE complex, displaces the SNAP-25 protein and takes its place in the SNARE complex, which leads to a weakening of muscle contraction and a reduction in the depth of wrinkles caused by muscle contraction.

Active ingredients:

  • ARGIRELIN, 10% with a Botox effect that acts on mimic wrinklesSodium hyaluronate to fill fine wrinkles on the whole face
  • Panthenol for skin hydration
  • Vitamin E as an antioxidant
  • Marigold extract with a calming effect
  • Avocado oil that nourishes the skin and stimulates collagen synthesis
  • Bisabolol for better penetration of active ingredients into deeper layers of the skin

Serum active ingredients:

  • SNAP-8 with Botox effect that acts on mimic wrinkles
    Sodium hyaluronate for filling fine wrinkles
    Witch hazel extract which as an astringent shrinks enlarged facial pores
    Panthenol for skin hydration
    Colloidal oat mixture with beta glucans that forms a protective film on the skin
    Aloe juice for hydration and preservation of skin integrity
    Bisabolol for better penetration of active ingredients into deeper layers of the skin

ARGIRELIN is a hexapeptide that reduces the depth of wrinkles by acting directly on muscle contraction.

Visible effects were observed after 7 days of application. Studies have shown that it prolongs the effect of Botox injections.

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Pharmacy Online has a contract with the Daily Express courier service and it is delivered on the territory of the Republic of Serbia through this service. Exports of goods to foreign countries are done through DHL and PostExport.

For all orders received up to 12h from Monday to Friday, the approximate delivery time is 2-4 business days for the whole territory of the Republic of Serbia. In case the order is placed on weekends (Saturdays and Sundays), the delivery is done as well as for the orders received on Monday - so next business day.

Deliveries are not made on Saturdays and Sundays.

Additional information

The items will be packed so that they cannot be damaged by normal handling of the goods in transit. When picking up the product, the buyer is obliged to check for any damage and immediately advertise it to the courier who delivered the goods, or refuse to take over the shipment, which shows the external damage. Any subsequent product claims for shipping damage will not be considered.

When picking up the product, the customer is required to sign the delivery note taken by the Daily Express delivery worker. The delivery note is considered to be a receipt and delivery note.

The courier service delivers the goods to the address, ie. does not bring into the living space.

Delivery restrictions on goods

Delivery of items purchased on the site www.apotekaonline.rs is made exclusively through the Daily Express courier service in the territory of the Republic of Serbia. Delivery outside the territory of the Republic of Serbia, ie export of goods, is done exclusively through the service of DHL and PostExport Post of Serbia.

Shipping cost

For the territory of the Republic of Serbia:

For goods ordered up to 3,000.00 RSD, delivery charge is 260.00 RSD (VAT included). For goods over 3,000.00 RSD, shipping is free of charge.

For international delivery:

For the export of goods abroad through the PostExport service of Post of Serbia, the shipping price is for:

  • Zone I (Slovenia, Croatia, Bosnia and Herzegovina, Montenegro, Northern Macedonia) - 1,280.00 RSD
  • Zone II (Other European countries) - 1,790.00 RSD
  • Zone III (Asia, Africa, America, Australia and other countries) - 2,650.00 RSD

Delivery time is 15 days or more (depending on the country of delivery)

For export of goods abroad through DHL service, the shipping price is 2,700.00 RSD. Delivery time is 1-5 business days (depending on the country of delivery)

Shipping cost is with tax. The price includes the delivery of the parcel to the buyer's address with the associated tax and customs at the seller's expense. A possible additional cost may be a customs charge against the buyer, depending on the country to which the package is being shipped.

For any additional questions, complaints or checking the current location of your shipment, please contact us at the following e-mail address: [email protected]

Tags: botofill , krema , + , botofill , serum , skin , care